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Related Experiment Video

Updated: Feb 2, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

GPIIb/IIIa expression changes in atrial fibrillation post radiofrequency ablation.

Y-Q Song¹, W-J Xu, C-L Lin

¹Department of Cardiology, Beijing Ditan Hospital, Capital Medical University, Beijing, China. ziduan311557@163.com.

European Review for Medical and Pharmacological Sciences

|November 8, 2018

Summary

Increased GPIIb/IIIa levels after atrial fibrillation ablation correlate with recurrence risk. This marker, associated with platelet aggregation, may indicate post-procedure myocardial injury and predict outcomes.

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Area of Science:

Cardiology
Hematology
Biochemistry

Background:

Atrial fibrillation (AF) is a common arrhythmia impacting quality of life and increasing thromboembolism risk.
Patients with AF often exhibit hypercoagulation, potentially worsening prognosis.
Glycoprotein IIb/IIIa (GPIIb/IIIa) is a key fibrinogen receptor involved in platelet aggregation and can serve as a hemagglutination marker.

Purpose of the Study:

To analyze changes in GPIIb/IIIa levels following radiofrequency ablation (RFA) for AF.
To investigate the relationship between GPIIb/IIIa levels and AF recurrence after RFA.

Main Methods:

Enrolled 80 AF patients undergoing RFA and 40 healthy controls.
Measured GPIIb/IIIa via ELISA; assessed hs-cTnT, FPG, HDL, LDL, TC, TG via electrochemical luminescence.
Recorded BMI, smoking index, and age.

Main Results:

The recurrence group showed elevated GPIIb/IIIa, hs-cTnT, FPG, LDL, TC, and TG, with decreased HDL compared to the non-recurrence group (p < 0.05).
GPIIb/IIIa positively correlated with hs-cTnT, FPG, LDL, TC, TG, BMI, and smoking index, and negatively with HDL (p < 0.05).
Higher GPIIb/IIIa levels were significantly associated with postoperative AF recurrence (p < 0.05).

Conclusions:

Elevated GPIIb/IIIa expression post-RFA for AF is linked to myocardial injury.
Increased GPIIb/IIIa suggests a heightened risk of postoperative recurrence in AF patients.