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Circadian disruption: What do we actually mean?

Céline Vetter1

  • 1Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado.

The European Journal of Neuroscience
|November 8, 2018
PubMed
Summary

Circadian disruption, from jet lag to shift work, impacts health. Clear terminology and quantifiable measures are crucial for advancing circadian science and improving health outcomes.

Keywords:
chronic diseasechronotypecircadian desynchronizationcircadian desynchronycircadian misalignmentsocial jetlag

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Area of Science:

  • Chronobiology
  • Human Physiology
  • Sleep Science

Background:

  • The circadian system governs physiological and behavioral rhythms.
  • Challenges like jet lag and shift work cause circadian disruption, leading to adverse health effects.
  • Existing terminology for circadian disruption lacks standardization.

Purpose of the Study:

  • To review terms used for circadian disruption.
  • To discuss methods for quantifying circadian disruption in humans.
  • To identify limitations in current assessment tools.

Main Methods:

  • Literature review of terms and quantification methods for circadian disruption.
  • Focus on human research, including experimental and observational studies.
  • Analysis of limitations and challenges of existing tools.

Main Results:

  • Multiple terms describe circadian disruption, causing ambiguity.
  • Quantification methods vary, with limitations in operationalization and scalability.
  • Need for standardized, validated tools for assessing circadian disruption.

Conclusions:

  • Standardized terminology and robust quantification are essential for translational circadian research.
  • Improved assessment will enhance reproducibility and facilitate clinical applications.
  • Advancing circadian science requires clear, scalable metrics for disruption.