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Updated: Feb 2, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
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Left Ventricular Ejection Fraction Predicts Poststroke Cardiovascular Events and Mortality in Patients without Atrial

Jeong Yoon Lee1, Jun Sang Sunwoo1, Kyum Yil Kwon1

  • 1Department of Neurology, Soonchunhyang University School of Medicine, Seoul, Korea.

Korean Circulation Journal
|November 8, 2018
PubMed

Insights

Left ventricular ejection fraction (LVEF) predicts cardiovascular events and mortality in acute ischemic stroke patients without atrial fibrillation or coronary heart disease. Lower LVEF indicates higher risk for adverse outcomes.

Area of Science:

  • Cardiology
  • Neurology
  • Echocardiography

Background:

  • Decreased left ventricular function's role in post-stroke outcomes is debated.
  • Existing research often includes patients with atrial fibrillation or coronary heart disease, confounding results.

Purpose of the Study:

  • To determine if left ventricular ejection fraction (LVEF) predicts cardiovascular events and mortality in acute ischemic stroke (AIS) patients without atrial fibrillation (AF) and coronary heart disease (CHD).

Main Methods:

  • 1,465 AIS patients without AF/CHD underwent transthoracic echocardiography.
  • Clinical data and LVEF were analyzed.
  • 1-year post-stroke outcomes (disability, MACE, mortality) were prospectively captured and analyzed using Cox regression.

Main Results:

  • Lower LVEF (<55) was associated with significantly higher rates of major adverse cardiac events (MACE) and all-cause mortality.
  • Each 10% decrease in LVEF showed a 46% reduced risk for MACE and a 39% reduced risk for all-cause mortality.
  • LVEF proved to be an independent predictor in adjusted models.

Conclusions:

  • Left ventricular ejection fraction (LVEF) is an independent predictor of cardiovascular events and mortality after acute ischemic stroke (AIS).
  • This finding holds true even in the absence of atrial fibrillation (AF) and coronary heart disease (CHD).
  • LVEF assessment can aid in risk stratification for AIS patients.
Abstract

Keywords:
EchocardiographyLeft ventricular functionMortalityStroke

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