Spectrum of Voriconazole-Induced Periostitis With Review of the Differential Diagnosis

Area of Science:

• Medical Imaging
• Pharmacology
• Radiology

Background:

• Voriconazole is a key antifungal agent for Candida and Aspergillus infections.
• Periostitis is an emerging side effect associated with prolonged voriconazole therapy.
• Accurate diagnosis is crucial for patient management.

Purpose of the Study:

• To describe voriconazole-induced periostitis.
• To differentiate this condition from hypertrophic osteoarthropathy.
• To outline other potential differential diagnoses.

Main Methods:

• Review of imaging findings associated with voriconazole-induced periostitis.
• Comparison with clinical and imaging features of differential diagnoses.
• Analysis of clinical manifestations and outcomes.

Main Results:

• Voriconazole-induced periostitis presents with characteristic imaging features.
• Key differentials include hypertrophic osteoarthropathy, venous stasis, thyroid acropachy, and hypervitaminosis A.
• Understanding these features aids in accurate diagnosis.

Conclusions:

• Radiologists can accurately diagnose voriconazole-induced periostitis.
• Knowledge of imaging appearance, clinical signs, and outcomes is essential.
• Appropriate management can be initiated by clinical teams upon diagnosis.