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Updated: Feb 2, 2026

Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
Research progress of circular RNAs in lung cancer
Yi Ma1, Xin Zhang1, Yi-Zhi Wang1
1a Department of thoracic surgery , First Affiliated Hospital of China Medical University , Shenyang , Liaoning , China.
Abstract:
Lung cancer is one of the most common cancers and the leading cause of cancer-related death worldwide. Despite encouraging results achieved with targeted therapy in recent years, the early diagnosis and treatment of lung cancer remains a major problem. Circular RNA (circRNA), a type of RNA with covalently closed continuous loop structures, has structural stability and certain tissue specificity. Recent studies have found that circRNAs have an important role in tumor development and are expected to be revealed as new targets for tumor prediction and treatment. Research on the biological functions and regulation mechanisms of circRNAs in lung cancer is in its infancy but is gathering momentum. In this review, we discuss the properties, biogenesis, biological function, and research progress of circRNAs in lung cancer to provide a theoretical foundation and new directions for studies on circRNAs in lung cancer.
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