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Alkali Metals03:06

Alkali Metals

24.6K
Group 1 elements are soft and shiny metallic solids. They are malleable, ductile, and good conductors of heat and electricity. The melting points of the alkali metals are unusually low for metals and decrease going down the group, while the density increases going down the group with the exception of potassium (Table 1).
Table 1: Properties of the alkali metals
24.6K
Bonding in Metals02:32

Bonding in Metals

52.4K
Metallic bonds are formed between two metal atoms. A simplified model to describe metallic bonding has been developed by Paul Drüde called the “Electron Sea Model”. 
52.4K
Metallic Solids02:37

Metallic Solids

20.6K
Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
20.6K
Metal-Ligand Bonds02:51

Metal-Ligand Bonds

24.3K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
24.3K
Properties of Transition Metals02:58

Properties of Transition Metals

29.8K
Transition metals are defined as those elements that have partially filled d orbitals. As shown in Figure 1, the d-block elements in groups 3–12 are transition elements. The f-block elements, also called inner transition metals (the lanthanides and actinides), also meet this criterion because the d orbital is partially occupied before the f orbitals.
29.8K
Second Order systems II01:18

Second Order systems II

408
In an underdamped second-order system, where the damping ratio ζ is between 0 and 1, a unit-step input results in a transfer function that, when transformed using the inverse Laplace method, reveals the output response. The output exhibits a damped sinusoidal oscillation, and the difference between the input and output is termed the error signal. This error signal also demonstrates damped oscillatory behavior. Eventually, as the system reaches a steady state, the error diminishes to zero.
408

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Systemic sclerosis and exposure to heavy metals.

Isabelle Marie1

  • 1Department of Internal medicine, CHU Rouen, INSERM U 905, University of Rouen IFRMP, Institute for Biochemical Research, Rouen, France.

Autoimmunity Reviews
|November 8, 2018
PubMed
Summary

Environmental factors significantly impact systemic sclerosis (SSc) development and progression. Identifying occupational exposures like silica, solvents, and heavy metals is crucial for early diagnosis and potential treatment improvements in SSc patients.

Keywords:
Ketones - welding fumes - pesticidesSolventsSystemic sclerosis - environmental factors - occupational factorsTrichloroethylenecrystalline silica

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Area of Science:

  • Environmental Medicine
  • Toxicology
  • Rheumatology

Background:

  • Systemic sclerosis (SSc) onset and progression are increasingly linked to environmental factors.
  • Epigenetic alterations play a role in SSc pathogenesis, influenced by environmental exposures.
  • Occupational exposures are recognized as significant contributors to SSc.

Purpose of the Study:

  • To highlight the environmental factors contributing to systemic sclerosis (SSc).
  • To identify potential future causative agents for SSc.
  • To emphasize the importance of checking occupational exposures in SSc patients.

Main Methods:

  • Review of scientific evidence correlating environmental factors with SSc.
  • Analysis of established links between SSc and occupational exposures.
  • Exploration of recent findings on heavy metal associations with SSc.

Main Results:

  • Strong correlation between SSc and occupational exposure to crystalline silica and organic solvents.
  • Emerging evidence links SSc to exposure to heavy metals such as antimony, cadmium, lead, and mercury.
  • Identification of specific toxic agents can lead to intervention.

Conclusions:

  • Environmental factors, particularly occupational exposures, are critical in SSc.
  • Systematic screening for heavy metal exposure in SSc patients is recommended.
  • Interrupting exposure to identified occupational toxins may improve SSc outcomes.