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Related Experiment Video

Updated: Feb 2, 2026

Electrophysiological Recordings from the Giant Fiber Pathway of D. melanogaster

Electrophysiological Recordings from the Giant Fiber Pathway of D. melanogaster

Published on: January 14, 2011

Giant Prolactinomas.

Ilan Shimon^1,2

¹Institute of Endocrinology, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel, ilanshi@clalit.org.il.

Neuroendocrinology

|November 8, 2018

Summary

This summary is machine-generated.

Giant prolactinomas, rare pituitary tumors, can be aggressive and invasive. Long-term treatment with dopamine agonists, surgery, or radiotherapy helps manage these prolactin-secreting adenomas.

Keywords:

Cabergoline Dopamine agonist Giant prolactinoma Prolactin Prolactinoma

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Last Updated: Feb 2, 2026

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Area of Science:

Endocrinology
Neurosurgery
Oncology

Background:

Prolactin-secreting adenomas (prolactinomas) are the most common pituitary tumors.
Microprolactinomas are common in women, while macroprolactinomas are more frequent in men.
Giant prolactinomas (>40 mm) are rare (1-5%) but aggressive and invasive.

Purpose of the Study:

To describe the characteristics of giant prolactinomas.
To outline the clinical presentation and management of giant prolactinomas.
To review treatment outcomes for patients with giant prolactinomas.

Main Methods:

Review of literature on giant prolactinomas.
Analysis of clinical data from patients with giant prolactinomas.
Discussion of therapeutic strategies for prolactinoma management.

Main Results:

Giant prolactinomas frequently invade surrounding structures like the suprasellar region and cavernous sinuses.
Visual impairment and ophthalmoplegia are common complications due to optic chiasm involvement.
Most patients achieve biochemical remission and tumor control with long-term treatment.

Conclusions:

Giant prolactinomas require aggressive management due to their invasive nature.
A multimodal approach including dopamine agonists, surgery, and radiotherapy is often necessary.
Long-term therapy is crucial for sustained tumor control and clinical improvement in prolactinoma patients.