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Updated: Feb 2, 2026

Plant Sample Preparation for Nucleoside/Nucleotide Content Measurement with An HPLC-MS/MS
Published on: February 24, 2021
Exploring the Emergence of RNA Nucleosides and Nucleotides on the Early Earth
1RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, 01605 MA, USA. annabelle.biscans@umassmed.edu.
Abstract:
Understanding how life began is one of the most fascinating problems to solve. By approaching this enigma from a chemistry perspective, the goal is to define what series of chemical reactions could lead to the synthesis of nucleotides, amino acids, lipids, and other cellular components from simple feedstocks under prebiotically plausible conditions. It is well established that evolution of life involved RNA which plays central roles in both inheritance and catalysis. In this review, we present historically important and recently published articles aimed at understanding the emergence of RNA nucleosides and nucleotides on the early Earth.
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