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AMP-Activated Protein Kinase and Host Defense against Infection

Prashanta Silwal1,2, Jin Kyung Kim3,4,5, Jae-Min Yuk6

  • 1Department of Microbiology, Chungnam National University School of Medicine, Daejeon 35015, Korea. pst.ktz@gmail.com.

International Journal of Molecular Sciences
|November 9, 2018
PubMed

Insights

5'-AMP-activated protein kinase (AMPK) impacts host defenses against infection, with its role varying by pathogen. Targeting AMPK offers potential for new treatments against infectious diseases.

Area of Science:

  • Biochemistry
  • Immunology
  • Infectious Diseases

Background:

  • 5 AMP-activated protein kinase (AMPK) is a key regulator of cellular energy metabolism.
  • AMPK activity is modulated by various pathogens, influencing host immune responses.
  • The role of AMPK in infection is complex and context-dependent.

Purpose of the Study:

  • To review the dual role of AMPK in innate and adaptive immunity during infections.
  • To explore how pathogens manipulate AMPK signaling pathways.
  • To highlight the therapeutic potential of targeting AMPK for infectious diseases.

Main Methods:

  • Literature review of studies on AMPK and infectious diseases.
  • Analysis of AMPK's involvement in host defense mechanisms.
  • Examination of pathogen-specific modulation of AMPK activity.

Main Results:

  • AMPK activation can be beneficial in some viral infections (e.g., Hepatitis B/C) but detrimental in others (e.g., Dengue, Ebola).
  • Pathogens actively manipulate AMPK signaling to evade host defenses.
  • AMPK-targeting agents show promise in enhancing antiviral and anti-infective responses.

Conclusions:

  • AMPK exhibits a "double-edged sword" role in host defense against pathogens.
  • Understanding AMPK's intricate regulation of immunity is crucial for developing host-directed therapies.
  • Targeting AMPK pathways presents a promising strategy for combating infectious diseases.
Keywords:
AMPKhost defenseinfectionmycobacteria

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