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Unconventional Electrochemistry in Micro-/Nanofluidic Systems.

Sahana Sarkar1, Stanley C S Lai2, Serge G Lemay3

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Micromachines
|November 9, 2018
PubMed
Summary

Implementing reliable micrometer-scale reference electrodes is challenging for miniaturized electrochemistry systems. This review explores solutions and alternative strategies, including eliminating the need for a reference electrode.

Keywords:
bipolar electrodeelectrochemistryfloating electrodepotentiometryreference electrode

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Area of Science:

  • Analytical Chemistry
  • Electrochemistry
  • Miniaturized Systems

Background:

  • Electrochemistry offers a powerful detection method for miniaturized analytical systems.
  • A key challenge in developing these systems is the reliable integration of micrometer-scale reference electrodes.

Purpose of the Study:

  • To review the challenges associated with fabricating microscale reference electrodes.
  • To discuss various strategies for creating functional reference electrodes at the micrometer scale.
  • To explore alternative electrochemical techniques that circumvent the need for a reference electrode.

Main Methods:

  • Review of existing literature on microscale reference electrode fabrication.
  • Discussion of established and novel approaches for reference electrode implementation.
  • Analysis of alternative electrochemical cell configurations and techniques.

Main Results:

  • Identified key challenges in the design and fabrication of reliable micrometer-scale reference electrodes.
  • Presented a comprehensive overview of current strategies for building suitable microreferences.
  • Highlighted alternative electrochemical methods that eliminate the requirement for a reference electrode.

Conclusions:

  • Overcoming reference electrode limitations is crucial for advancing miniaturized electrochemical systems.
  • Alternative strategies offer promising pathways for simplified and robust electrochemical sensing.
  • Further research into reference-free electrochemical techniques can drive innovation in portable analysis.