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Updated: Feb 2, 2026
07:53
Using Adhesive Patterning to Construct 3D Paper Microfluidic Devices
Published on: April 1, 2016
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3D Printed Paper-Based Microfluidic Analytical Devices.
Yong He1,2,3, Qing Gao4,5, Wen-Bin Wu6,7
1State Key Laboratory of Fluid Power and Mechatronic Systems, College of Mechanical Engineering, Zhejiang University, Hangzhou 310027, China. yongqin@zju.edu.cn.
Micromachines
|November 9, 2018
Summary
This study introduces a novel, low-cost paper-based microfluidic analytical device (μPAD) fabricated using 3D printing. It utilizes cellulose powder for programmable capillary flow, enabling advanced analytical sequences for point-of-care applications.
Area of Science:
- Analytical Chemistry
- Materials Science
- Microfluidics
Background:
- Paper-based microfluidic analytical devices (μPADs) offer pump-free, lightweight analytical capabilities.
- Programming the flow speed in μPADs is crucial for designing complex analytical sequences and enhancing their utility.
Purpose of the Study:
- To develop a novel μPAD with easy fabrication and programmable flow speed.
- To demonstrate the device's capability in quantitative analysis and sensor fabrication.
Main Methods:
- Fabrication of a 3D printed substrate with microchannels.
- Sealing microchannels with polydimethylsiloxane (PDMS).
- Utilizing a cellulose powder and deionized water mixture to drive capillary flow, with channel depth controlling flow speed.
Main Results:
- Demonstrated programmable capillary flow speed by varying microchannel depths.
- Successfully performed quantitative analysis of nitrite ions.
- Fabricated a T-sensor to showcase the device's versatility.
Conclusions:
- The 3D printed μPAD offers an accessible, low-cost platform for analytical chemistry.
- Programmable capillary flow enables sophisticated analytical designs.
- The device shows significant potential for point-of-care (POC) systems and field testing.
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