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Related Experiment Video

Updated: Feb 2, 2026

Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance

Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance

Published on: September 26, 2017

Cytostretch, an Organ-on-Chip Platform.

Nikolas Gaio¹, Berend van Meer², William Quirós Solano³

¹Laboratory of Electronic Components, Technology & Materials (ECTM), DIMES, Delft University of Technology, 2628 CD Delft, The Netherlands. n.gaio@tudelft.nl.

|November 9, 2018

Summary

This summary is machine-generated.

A new modular Cytostretch membrane platform enables customizable Organ-on-Chips (OOCs) for mimicking human organ functions. This versatile technology supports diverse applications through silicon micro-fabrication for low-cost, high-volume production.

Keywords:

Cytostretch customizable micro-electrode array micro-grooves modular organ-on-chip platform stem cells strain gauges through-membrane pores

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Related Experiment Videos

Last Updated: Feb 2, 2026

Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance

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Published on: September 26, 2017

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

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Published on: April 28, 2015

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

Area of Science:

Biotechnology
Tissue Engineering
Microfluidics

Background:

Organ-on-Chips (OOCs) are microfluidic devices mimicking human organ physiological environments.
Current OOCs often focus on single organ functional units.
In situ electrical/mechanical stimulation is crucial for mimicking in vivo conditions.

Purpose of the Study:

To introduce a modular Cytostretch membrane platform for versatile OOC customization.
To demonstrate silicon-based micro-fabrication for scalable OOC manufacturing.
To present functional modules for advanced OOC applications.

Main Methods:

Development of a modular Cytostretch membrane platform.
Utilizing silicon-based micro-fabrication techniques.
Integration of functional membrane variants: transwell pores, micro-electrode arrays, micro-patterning, and strain gauges.

Main Results:

Successful fabrication and proof-of-functionality for each Cytostretch membrane module.
Demonstrated capability for creating a wide range of customized OOCs.
Enabled low-cost, high-volume manufacturing of OOCs.

Conclusions:

The Cytostretch platform offers a customizable and scalable solution for Organ-on-Chips development.
The modular design facilitates diverse OOC applications by integrating various functionalities.
This technology advances the field of OOCs for physiological and pathological studies.