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A Pilot Clinical Study of Liquid Ubiquinol Supplementation on Cardiac Function in Pediatric Dilated Cardiomyopathy

Fong-Lin Chen1,2,3, Po-Sheng Chang4,5, Yi-Chin Lin6

  • 1Department of Pediatrics, Chung Shan Medical University Hospital, Taichung 40201, Taiwan. cshy053@gmail.com.

Nutrients
|November 9, 2018
PubMed

Insights

Liquid ubiquinol supplementation improved cardiac function in children with pediatric dilated cardiomyopathy (PDCM). This hydrophilic nutrient increased coenzyme Q10 levels, enhancing ejection fraction and fractional shortening, and reducing heart failure symptoms.

Area of Science:

  • Cardiology
  • Pediatrics
  • Nutritional Science

Background:

  • Pediatric dilated cardiomyopathy (PDCM) is a severe cardiac condition in children.
  • Ubiquinone (CoQ10) is vital for cellular energy production.
  • A new hydrophilic ubiquinol supplement offers potential therapeutic benefits.

Purpose of the Study:

  • To evaluate the impact of liquid ubiquinol on cardiac function in children with PDCM.
  • To assess changes in New York Heart Association (NYHA) classification.
  • To correlate plasma coenzyme Q10 levels with cardiac performance.

Main Methods:

  • Ten children with PDCM received liquid ubiquinol (10 mg/kg/day) for 24 weeks.
  • Cardiac function assessed via echocardiography (EF, FS).
  • NYHA classification and plasma coenzyme Q10 levels were monitored.

Main Results:

  • Ejection fraction (EF) and fractional shortening (FS) significantly improved up to week 16.
  • Higher plasma coenzyme Q10 correlated with better EF and FS.
  • 30% of participants showed improved NYHA functional classification after 24 weeks.

Conclusions:

  • Liquid ubiquinol supplementation effectively increases coenzyme Q10 levels in children with PDCM.
  • Supplementation demonstrates a positive effect on cardiac function (EF, FS).
  • Ubiquinol may ameliorate heart failure symptoms in pediatric patients.
Abstract

Keywords:
coenzyme Q10dietary supplementationheart failureliquid ubiquinolpediatric dilated cardiomyopathypediatric nutrition

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