Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

66.1K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
66.1K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

16.5K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.5K
What is the Immune System?01:38

What is the Immune System?

128.1K
Overview
128.1K
Humoral Immune Responses01:36

Humoral Immune Responses

83.9K
Overview
83.9K
Perpendicular-Axis Theorem01:16

Perpendicular-Axis Theorem

4.6K
The perpendicular-axis theorem states that the moment of inertia of a planar object about an axis perpendicular to its plane is equal to the sum of the moments of inertia about two mutually perpendicular concurrent axes lying in the plane of the body.
Consider a circular disc of mass M and radius R lying along an x-y plane. The origin lies at the center of the disc, and the z-axis is perpendicular to the disc's plane. All three axes coincide at the disc's center. The moment of inertia of this...
4.6K
Parallel-axis Theorem01:06

Parallel-axis Theorem

8.3K
The parallel-axis theorem provides a convenient and quick method of finding the moment of inertia of an object about an axis parallel to the axis passing through its center of mass. Consider a thin rod as an example. There is a striking similarity between the process of finding the moment of inertia of a thin rod about an axis through its middle, where the center of mass lies, and about an axis through its end using the conventional method. In the conventional method, the concept of linear mass...
8.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The fate of neuronal synapse homeostasis in aging, infection, and inflammation.

American journal of physiology. Cell physiology·2024
Same author

Astrocytes evoke a robust IRF7-independent type I interferon response upon neurotropic viral infection.

Journal of neuroinflammation·2023
Same author

Same but different? A qualitative analysis of the influence of COVID-19 on law enforcement and organized crime in Germany.

Trends in organized crime·2022
Same author

Influenza A Virus (H1N1) Infection Induces Microglial Activation and Temporal Dysbalance in Glutamatergic Synaptic Transmission.

mBio·2021
Same author

Physiologically Based Pharmacokinetic/Pharmacodynamic Model for the Treatment of Dengue Infections Applied to the Broad Spectrum Antiviral Soraphen A.

ACS pharmacology & translational science·2021
Same author

Contact-dependent transmission of Langat and tick-borne encephalitis virus in type I interferon receptor-1 deficient mice.

Journal of virology·2021

Related Experiment Video

Updated: Feb 2, 2026

Author Spotlight: Investigating the Complex Immune Response Following Brain Ischemia
06:28

Author Spotlight: Investigating the Complex Immune Response Following Brain Ischemia

Published on: July 26, 2024

4.7K

The brain-immune cells axis controls tissue specific immunopathology.

Maxi Heyner1, Sarah Schreier1, Andrea Kröger2,3

  • 1Institute for Medical Microbiology and Hospital Hygiene, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.

Cellular & Molecular Immunology
|November 9, 2018
PubMed
Summary

Viral infections cause cell death through direct viral damage or immune responses, leading to tissue injury. Host mechanisms balance pathogen elimination with preventing fatal damage.

More Related Videos

Using Fluorescence Activated Cell Sorting to Examine Cell-Type-Specific Gene Expression in Rat Brain Tissue
08:37

Using Fluorescence Activated Cell Sorting to Examine Cell-Type-Specific Gene Expression in Rat Brain Tissue

Published on: May 28, 2015

17.5K
Isolation of Adipose Tissue Immune Cells
07:09

Isolation of Adipose Tissue Immune Cells

Published on: May 22, 2013

37.1K

Related Experiment Videos

Last Updated: Feb 2, 2026

Author Spotlight: Investigating the Complex Immune Response Following Brain Ischemia
06:28

Author Spotlight: Investigating the Complex Immune Response Following Brain Ischemia

Published on: July 26, 2024

4.7K
Using Fluorescence Activated Cell Sorting to Examine Cell-Type-Specific Gene Expression in Rat Brain Tissue
08:37

Using Fluorescence Activated Cell Sorting to Examine Cell-Type-Specific Gene Expression in Rat Brain Tissue

Published on: May 28, 2015

17.5K
Isolation of Adipose Tissue Immune Cells
07:09

Isolation of Adipose Tissue Immune Cells

Published on: May 22, 2013

37.1K

Area of Science:

  • Virology
  • Immunology
  • Cell Biology

Background:

  • Viral infections can directly cause cell death via cytopathic virus replication.
  • Host immune responses to viruses also induce cell death and subsequent tissue damage.
  • A critical balance exists between eliminating pathogens and preventing fatal host tissue damage.

Purpose of the Study:

  • To investigate the mechanisms of virus-induced cell death.
  • To understand the role of host immune responses in viral pathogenesis.
  • To explore host strategies for regulating immune-mediated tissue damage during viral infections.

Main Methods:

  • Analysis of cytopathic effects in infected cell cultures.
  • Assessment of inflammatory cell infiltration and tissue damage markers.
  • Investigation of host-derived molecular pathways that regulate cell death and inflammation.

Main Results:

  • Cytopathic virus replication directly induces cell death in various cell types.
  • Immune cell infiltration following viral infection contributes significantly to tissue damage.
  • Host mechanisms are crucial for modulating the immune response to prevent excessive damage.

Conclusions:

  • Cell death during viral infections is a complex process involving both direct viral action and host immune responses.
  • Effective viral clearance necessitates a tightly regulated immune response to mitigate potentially fatal tissue damage.
  • Understanding these host mechanisms is key to developing therapeutic strategies for viral diseases.