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Luteolin exerts an anticancer effect on gastric cancer cells through multiple signaling pathways and regulating

Yansong Pu1, Tao Zhang1, Jianhua Wang1

  • 1The Second Department of General Surgery, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, P.R. China.

Journal of Cancer
|November 9, 2018
PubMed

Insights

Luteolin, a plant flavonoid, demonstrates significant anticancer effects against gastric cancer (GC) by inhibiting cell viability and promoting apoptosis. This study explores its molecular mechanisms, revealing potential therapeutic applications for GC treatment.

Area of Science:

  • Molecular Biology
  • Pharmacology
  • Oncology

Background:

  • Luteolin is a dietary flavonoid with known antioxidant, anti-inflammatory, and anticancer properties.
  • The precise mechanisms of luteolin's action against gastric cancer (GC) remain largely unelucidated.
  • Understanding luteolin's molecular targets is crucial for developing novel GC therapies.

Purpose of the Study:

  • To investigate the anticancer effects of luteolin on gastric cancer (GC) cells.
  • To elucidate the underlying molecular mechanisms of luteolin's anti-GC activity.
  • To assess the therapeutic potential of luteolin as an agent for human GC.

Main Methods:

  • Evaluated luteolin's impact on GC cell viability, proliferation, apoptosis, migration, and invasion in vitro and in vivo.
  • Analyzed the regulation of key signaling pathways including Notch1, PI3K/AKT/mTOR, ERK, STAT3, and p38.
  • Investigated the modulation of microRNA (miRNA) expression profiles following luteolin treatment.

Main Results:

  • Luteolin significantly reduced GC cell viability, proliferation, migration, and invasion in a dose- and time-dependent manner.
  • Luteolin treatment promoted apoptosis in GC cells.
  • Luteolin modulated multiple signaling pathways (Notch1, PI3K/AKT/mTOR, ERK, STAT3, p38) and altered miRNA expression.

Conclusions:

  • Luteolin exhibits potent anticancer effects against gastric cancer through multifaceted molecular mechanisms.
  • The study provides novel insights into luteolin's molecular functions in regulating GC progression.
  • Luteolin shows promise as a potential therapeutic agent for human gastric cancer.
Keywords:
EMTLuteolingastric cancermetastasisprognosis

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