Related Experiment Video
Updated: Feb 2, 2026

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
Published on: October 17, 2025
An observational study of Chinese adults with relapsed/refractory Philadelphia-negative acute lymphoblastic leukemia
Jun Ma1,1, Ting Liu2,2, Jie Jin3,3
1Department of Hematology, Harbin Institute of Hematology & Oncology, Harbin, China.
Aim:
Chinese adults with relapsed/refractory Philadelphia chromosome-negative B-cell precursor acute lymphoblastic leukemia (Ph- ALL) have poor outcomes.
Patients & Methods:
We conducted a nationwide, retrospective, observational study to assess outcomes in this patient population.
Results:
Of the 270 enrolled patients, 31% of patients at last salvage achieved complete remission (CR) or CR with partial hematologic recovery (CRh), with median time to CR/CRh of 30 days and median CR/CRh duration of 2.7 months. The CR/CRh rate was more favorable with earlier versus later lines of salvage (41, 24 and 17% at first, second and third or later salvages, respectively).
Conclusion:
This dataset serves as an important reference of real-world outcomes using currently available chemotherapy regimens for high-risk Chinese adults with relapsed/refractory Ph- ALL.
Related Concept Videos
Observational Studies
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
Naturalistic Observations
Acute Pyelonephritis II: Diagnostic Studies and Management
Negative Regulator Molecules
Positive, Negative, and Zero Work
Acute Coronary Syndrome III: Diagnostic Studies

