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Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
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Multicellular Interactions in 3D Engineered Myocardial Tissue

Maedeh Zamani1,2, Esra Karaca1,2,3, Ngan F Huang1,2,3

  • 1School of Medicine, The Stanford Cardiovascular Institute, Stanford University, Stanford, CA, United States.

Frontiers in Cardiovascular Medicine
|November 9, 2018
PubMed

Insights

Engineering myocardial tissue with organized multicellular structures shows promise for treating cardiovascular disease. This approach aims to improve cardiac function beyond current cell therapies by leveraging cell interactions for cardiomyocyte health.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Tissue Engineering

Background:

  • Cardiovascular disease remains a primary global cause of mortality.
  • Current cell therapies offer limited improvement in cardiac pumping capacity.
  • Cardiomyocytes (CMs) require interaction with non-cardiomyocyte cells for optimal function.

Purpose of the Study:

  • To review progress in engineering myocardial tissue with physiological multicellular organization.
  • To highlight the role of non-cardiomyocyte populations in engineered heart tissue.
  • To identify challenges for clinical translation of these engineered tissues.

Main Methods:

  • Review of current literature on engineered myocardial tissue.
  • Analysis of cell-cell interactions and paracrine signaling in engineered tissues.
  • Evaluation of strategies for pre-forming physiological multicellular structures.

Main Results:

  • Non-cardiomyocyte cells (endothelial cells, fibroblasts) are crucial for CM survival and function in engineered tissues.
  • Paracrine factors and direct cell-cell interactions mediate beneficial effects.
  • Engineered tissues with organized multicellularity show potential for enhanced cardiac repair.

Conclusions:

  • Pre-formed physiological multicellular organization in engineered myocardial tissue is a promising strategy.
  • Overcoming challenges in clinical translation is essential for therapeutic application.
  • Further research is needed to optimize engineered heart tissue for treating cardiovascular disease.

Keywords:
cardiomyocytecardiovascular tissue engineeringco-cultureendothelial cellengineered myocardiumfibroblaststem cell

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