Cellular and Molecular Heterogeneity Associated with Vessel Formation Processes.

Area of Science:

• Vascular Biology
• Cellular and Molecular Biology

Background:

• Microvasculature heterogeneity presents a complex challenge in vascular biology due to fragmented knowledge.
• Understanding vessel formation processes (vasculogenesis, angiogenesis, arteriogenesis, lymphangiogenesis) is crucial for organ development and function.

Purpose of the Study:

• To provide an integrated view of microvasculature heterogeneity.
• To explore the interplay between neovascularisation processes and cellular/molecular diversity.
• To discuss the role of microvascular cells in tissue homeostasis and regulatory networks.

Main Methods:

• Review of existing literature on neovascularisation processes.
• Analysis of cellular and molecular heterogeneity in microvascular cells (endothelial and mural cells).
• Examination of interactions within blood-organ barriers and regulatory networks.

Main Results:

• Neovascularisation processes exhibit significant cellular and molecular heterogeneity.
• Microvascular cells display plasticity, adapting to tissue metabolic and physiological needs.
• Interactions within blood-organ barriers form an integrated regulatory network.

Conclusions:

• An integrated approach is necessary to comprehend microvasculature heterogeneity.
• Cellular and molecular diversity are key contributors to microcirculatory homeostasis.
• Specific molecular signatures control the cooperative network regulating microvasculature.