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Updated: Feb 2, 2026

Conventional BODIPY Conjugates for Live-Cell Super-Resolution Microscopy and Single-Molecule Tracking
Published on: June 8, 2020
AIE active piperazine appended naphthalimide-BODIPYs: photophysical properties and applications in live cell
Bhupendra Kumar Dwivedi1, Roop Shikha Singh1, Afsar Ali1
1Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221 005, UP, India. dsprewa@yahoo.com dspbhu@bhu.ac.in.
Abstract:
Piperazine appended naphthalimide-BODIPYs (NPB1-NPB4) exhibiting solvatochromism and aggregation-induced emission with a large Stokes shift (up to 146 nm) have been described. Separation of naphthalimide and BODIPY fluorophores by piperazine in these conjugates creates a donor-acceptor system and induces twisted intramolecular charge transfer, in addition to photoinduced electron transfer. The crucial role of naphthalimide, the alkyl chain length, the piperazine ring, and the solid-state packing on AIE has been extensively investigated by various studies. Superior cell permeability coupled with bio-compatibility of these conjugates offers a unique opportunity for their potential applications in live cell lysosomal tracking.
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