Related Experiment Video

Updated: Feb 2, 2026

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
09:41

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

Published on: July 15, 2015

9.1K

Multiple Myeloma of the Young - a Single Center Experience Highlights Future Directions

Ildikó Pál1, Árpád Illés1, László Váróczy2

  • 1Department of Hematology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, Debrecen, H-4032, Hungary.

Pathology Oncology Research : POR
|November 9, 2018
PubMed

Insights

Multiple myeloma is rare in young adults. This study found that young patients (≤40 years) had similar treatment responses but significantly better survival rates compared to older patients.

Area of Science:

  • Hematology
  • Oncology
  • Clinical Research

Background:

  • Multiple myeloma is uncommon in individuals younger than 40 years.
  • Understanding the characteristics and outcomes of young multiple myeloma patients is crucial.

Purpose of the Study:

  • To investigate the clinical features, treatment outcomes, and survival rates of multiple myeloma patients aged 40 years or younger.
  • To compare the outcomes of young multiple myeloma patients with those of older patients.

Main Methods:

  • Retrospective review of a database from 2006 to 2015.
  • Analysis of clinical data for 312 newly diagnosed multiple myeloma patients, focusing on a subgroup of 16 patients aged ≤40 years.
  • Comparison of survival data between young (≤40 years) and older (>40 years) patient groups.

Main Results:

  • Sixteen patients (5.1%) were diagnosed with multiple myeloma at age ≤40 years.
  • Young patients exhibited diverse clinical characteristics, similar to older populations.
  • Autologous stem cell transplantation was common in young patients, with comparable treatment responses to older patients.
  • Young patients demonstrated significantly better 5-year progression-free survival (48% vs. 35%) and overall survival (83% vs. 53%) compared to older patients.

Conclusions:

  • Younger multiple myeloma patients (≤40 years) experience superior survival outcomes compared to older counterparts.
  • Despite advancements, there remains a need for curative treatment strategies for young, fit multiple myeloma patients.
Keywords:
40 yearsMultiple myelomaOverall survivalProgression-free survivalYoung

More Related Videos

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis10:04

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Published on: May 1, 2015

13.5K
Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma07:53

Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma

Published on: April 15, 2022

4.7K

Related Concept Videos

Molecules with Multiple Chiral Centers02:25

Molecules with Multiple Chiral Centers

Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
15.1K
Lattice Centering and Coordination Number02:33

Lattice Centering and Coordination Number

The structure of a crystalline solid, whether a metal or not, is best described by considering its simplest repeating unit, which is referred to as its unit cell. The unit cell consists of lattice points that represent the locations of atoms or ions. The entire structure then consists of this unit cell repeating in three dimensions. The three different types of unit cells present in the cubic lattice are illustrated in Figure 1.
Types of Unit Cells
Imagine taking a large number of identical...
11.6K
Bioavailability Study Design: Single Versus Multiple Dose Studies01:11

Bioavailability Study Design: Single Versus Multiple Dose Studies

Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
243
Center of Gravity00:58

Center of Gravity

The center of gravity (COG) of an object is the point where the object's total weight is considered to be concentrated. Knowing the location of the center of gravity is useful when predicting the behavior of a moving object or designing static structures. In a uniform gravitational field, the center of gravity is similar to the center of mass (COM); yet, these two points can be positioned differently. For example, the Moon's center of mass lies very close to its geometric center, but...
6.7K
Center of Gravity01:15

Center of Gravity

The center of gravity is the point at which an object's weight appears to be concentrated and can be used to balance the object perfectly. This point is essential in mechanics as it provides information regarding a body's stability and moments of inertia. The center of gravity does not always have to fall within the shape or boundaries of the body; it may also lie outside the body in certain cases.
To determine its location, the principle of moments can be utilized by dividing the object into...
2.2K
Center of Mass00:59

Center of Mass

The center of mass is the point at which the total mass of an object can be said to be concentrated. It is a fundamental principle in mechanics and physics that applies to all objects regardless of their shape or size. The center of gravity is the point at which an object’s weight appears to be concentrated and can be used to balance the object perfectly.
The knowledge of the center of mass can also help us to describe and predict the motion of objects. For example, when a ball is thrown...
2.0K