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Updated: Feb 2, 2026

The ITS2 Database

The ITS2 Database

Published on: March 12, 2012

The EcoCyc Database.

Peter D Karp¹, Wai Kit Ong¹, Suzanne Paley¹

¹Bioinformatics Research Group, SRI International, Menlo Park, CA 94025.

|November 9, 2018

Summary

This summary is machine-generated.

EcoCyc is a comprehensive bioinformatics database detailing the Escherichia coli (E. coli) K-12 MG1655 genome and cellular functions. It provides extensive data on E. coli

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Area of Science:

Microbiology
Bioinformatics
Systems Biology

Background:

EcoCyc is a vital bioinformatics resource for studying Escherichia coli (E. coli) K-12 MG1655.
It aims to catalog the complete molecular components and functions within an E. coli cell for systems-level understanding.

Purpose of the Study:

To review the data content and generation procedures of the EcoCyc database.
To highlight EcoCyc's utility for E. coli biologists and researchers of related microorganisms.

Main Methods:

Curated data collection and integration from various sources.
Development of information pages for genes, metabolites, reactions, operons, and pathways.
Generation of a steady-state metabolic flux model from EcoCyc data.

Main Results:

EcoCyc provides detailed information on E. coli gene products, metabolites, reactions, operons, and pathways.
The database includes data on gene essentiality and nutrient requirements for E. coli growth.
A metabolic flux model integrated with EcoCyc predicts metabolic rates under various conditions.

Conclusions:

EcoCyc serves as an essential electronic reference for E. coli research.
The database facilitates systems-level understanding through comprehensive molecular and functional data.
Integrated modeling capabilities enhance predictive power for metabolic studies.