Inflammatory markers and left ventricular diastolic dysfunction in a family-based population study
Małgorzata Kloch1, Katarzyna Stolarz-Skrzypek2, Agnieszka Olszanecka3
1Department of Medical Education, Jagiellonian University Medical College, Krakow Poland.
Insights
Inflammation, indicated by elevated interleukin-6 (IL-6) and C-reactive protein (CRP), is linked to left ventricular diastolic dysfunction (LVDD). These inflammatory markers may contribute to the development of LVDD, particularly in men and women respectively.
Area of Science:
- Cardiology
- Internal Medicine
- Biomarkers
Background:
- Heart failure encompasses conditions with preserved (HFPEF) and reduced (HFREF) ejection fraction.
- Treatments for HFPEF remain a significant clinical challenge.
Purpose of the Study:
- To investigate the relationship between inflammatory markers and left ventricular diastolic dysfunction (LVDD).
- This study was conducted within a family-based population cohort.
Main Methods:
- Echocardiography and serum inflammatory marker measurements (CRP, MPO, IL-6) were performed on 303 participants.
- Participants included 55% women (median age 49) and 45% men (median age 40).
Main Results:
- Interleukin-6 (IL-6) correlated with multiple diastolic function parameters (A, S/D ratio, E/A ratio, E', E, E/E' ratio).
- C-reactive protein (CRP) showed associations with E/A ratio in women and S/D ratio in both sexes.
- Myeloperoxidase (MPO) did not correlate with LVDD parameters. In men, E' was predicted by IL-6, age, and heart rate.
Conclusions:
- Inflammation, particularly via IL-6 and CRP, is associated with LVDD.
- Inflammation may contribute to LVDD development, potentially through vascular endothelial dysfunction.
Background:
Heart failure affects patients with normal left ventricular systolic function (heart failure with preserved ejection fraction [HFPEF]) and those with reduced ejection fraction (HFREF). The treatment of HFPEF remains an unresolved issue.
Aim:
We sought to determinate the relationship between inflammatory markers and left ventricular diastolic dysfunction (LVDD) in a family-based population study.
Methods:
A total of 303 participants from the general population (55% women, median age 49 years and 45% men, median age 40 years) underwent echocardiography and measurement of serum inflammatory markers: C-reactive protein (CRP), myeloperoxidase (MPO), and interleukin 6 (IL-6).
Results:
Serum IL-6 concentration correlated with peak transmitral late diastolic velocity (A) and pulmonary vein systolic-to-di-astolic velocity (S/D) ratio (p < 0.01). Moreover, a significant correlation between IL-6 concentration and E/A ratio and early diastolic peak velocities of the mitral annulus displacement (E') was observed. The association of IL-6 concentration and peak transmitral early diastolic velocities (E) and the E/E' ratio (p < 0.05) was noted in men. In addition, the CRP concentration was shown to have an effect on E/A ratio in women (p < 0.05). A significant correlation between the CRP concentration and S/D ratio was observed both in women (p < 0.01) and men (p < 0.05). No significant correlation was found between the level of MPO and LVDD parameters. Additionally, only one predictive model was identified; E' was found to be dependent on IL-6, age, and heart rate in men (p < 0.001, R2 = 0.611).
Conclusions:
The above results suggest that inflammation may lead to the onset of LVDD, probably via vascular endothelial dysfunction.
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