Inflammatory markers and left ventricular diastolic dysfunction in a family-based population study

Area of Science:

• Cardiology
• Internal Medicine
• Biomarkers

Background:

• Heart failure encompasses conditions with preserved (HFPEF) and reduced (HFREF) ejection fraction.
• Treatments for HFPEF remain a significant clinical challenge.

Purpose of the Study:

• To investigate the relationship between inflammatory markers and left ventricular diastolic dysfunction (LVDD).
• This study was conducted within a family-based population cohort.

Main Methods:

• Echocardiography and serum inflammatory marker measurements (CRP, MPO, IL-6) were performed on 303 participants.
• Participants included 55% women (median age 49) and 45% men (median age 40).

Main Results:

• Interleukin-6 (IL-6) correlated with multiple diastolic function parameters (A, S/D ratio, E/A ratio, E', E, E/E' ratio).
• C-reactive protein (CRP) showed associations with E/A ratio in women and S/D ratio in both sexes.
• Myeloperoxidase (MPO) did not correlate with LVDD parameters. In men, E' was predicted by IL-6, age, and heart rate.

Conclusions:

• Inflammation, particularly via IL-6 and CRP, is associated with LVDD.
• Inflammation may contribute to LVDD development, potentially through vascular endothelial dysfunction.