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Updated: Feb 2, 2026

Isolation of Primary Mouse Trophoblast Cells and Trophoblast Invasion Assay
Published on: January 8, 2012
Gestational Trophoblastic Tumors: A Timely Review of Diagnostic Pathology
1From the Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.
Context.—:
Gestational trophoblastic tumors include 3 distinct entities: gestational choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor. Accurate diagnosis is important for clinical management of the patient.
Objective.—:
To review clinical features and pathologic diagnosis of gestational trophoblastic tumors.
Data Sources.—:
Literature and personal experience are the sources for this study.
Conclusions.—:
Trophoblastic tumors are rare encounters in modern medicine, as a result of clinical practice of molar surveillance programs and early chemotherapeutic intervention for persistent gestational trophoblastic neoplasia. Diagnostic recognition of these tumors requires a high index of suspicion, awareness of their histologic characteristics, and appropriate application of immunohistochemical and molecular biomarkers. Recent attention has been given to a few precursor lesions of gestational trophoblastic tumors, including early/in situ choriocarcinoma and atypical placental site nodule.
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