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Nervous system involvement in Behçet's syndrome.
1Department of Neurology, Istanbul University Cerrahpaşa School of Medicine, Istanbul, Turkey.
Current Opinion in Rheumatology
|November 9, 2018
Summary
Neuro-Behçet's syndrome (NBS) involves neurological symptoms in Behçet's syndrome patients. Distinct MRI patterns, like the "Bagel Sign," aid diagnosis, guiding treatment for this serious condition.
Area of Science:
- Neurology
- Immunology
- Radiology
Background:
- Behçet's syndrome (BS) is a multisystem inflammatory disorder.
- Neurological involvement (NBS) in BS carries a poor prognosis.
- Accurate diagnosis of NBS is crucial due to differing treatment options.
Purpose of the Study:
- To describe the differential diagnosis of neuro-Behçet's syndrome (NBS).
- To highlight radiological patterns of NBS.
- To outline treatment options for NBS.
Main Methods:
- Review of neurological involvement in Behçet's syndrome.
- Analysis of magnetic resonance imaging (MRI) findings.
- Consideration of cerebrospinal fluid (CSF) examination.
Main Results:
- Two distinct MRI patterns of spinal cord involvement in BS: 'Bagel Sign' and 'Motor Neuron' patterns.
- The 'Bagel Sign' pattern shows a central lesion with specific T2-weighted characteristics.
- The 'Motor Neuron' pattern involves symmetric anterior horn cell involvement.
- Infliximab treatment showed efficacy in preventing further attacks and improving neurological status.
Conclusions:
- Careful diagnosis of NBS is essential, especially when clinical and MRI findings mimic other central nervous system inflammatory disorders.
- Radiological patterns, particularly MRI findings, are key in diagnosing NBS.
- Effective treatment strategies, including Infliximab, can improve outcomes for patients with NBS.