Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Coagulation01:06

Coagulation

1.4K
Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
1.4K
Coagulation01:09

Coagulation

10.5K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
10.5K
Abnormal Proliferation02:23

Abnormal Proliferation

5.2K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.2K
Data Reporting and Recording01:24

Data Reporting and Recording

5.4K
Reporting and recording are crucial in data documentation. The timely, thorough, and accurate documentation of facts is essential when recording patient data. Failure to record findings during an assessment or interpretation of a problem will result in loss of information and make the patient document unreliable. The reader is left with general impressions if the information is not specific. A recording is documenting data of the individual's health information in a traceable, secure, and...
5.4K
Respiratory System Abnormal Finding I: Inspection and Percussion01:30

Respiratory System Abnormal Finding I: Inspection and Percussion

831
Respiratory system abnormalities are a significant concern in healthcare due to their potential to indicate underlying severe conditions like Chronic Obstructive Pulmonary Disease (COPD), asthma, and pneumonia. These abnormalities can often be detected through physical examination methods like inspection and percussion.
Inspection Findings
During an inspection, several findings may suggest the presence of respiratory distress or disease. Pursed-lip breathing, where exhalation is slowed by...
831
Cardiovascular System Abnormal Findings I: Inspection and Palpation01:29

Cardiovascular System Abnormal Findings I: Inspection and Palpation

886
In a cardiovascular examination, inspection and palpation are crucial for identifying abnormalities.
Abnormal findings observed during an inspection
886

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Architected Inverse Nacre Hydrogels With High Strength and Crack-Insensitive Toughness.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

CEDR: robust consensus cancer subtyping with multi-omics data via ensemble dimensionality reduction.

Briefings in bioinformatics·2026
Same author

Ultrafast Anion-Hopping Conduction in Organic Solvent via Imidazolium-Grafted Dynamic Ion-Conducting Spacers for Stable Non-Aqueous Flow Batteries.

Angewandte Chemie (International ed. in English)·2026
Same author

Decoupling conductivity and mechanics: Rational design of pre-constructed 3D skeletal organogels via interfacial engineering for high-performance sensing.

Journal of colloid and interface science·2026
Same author

An integrative association analysis for complex diseases in underrepresented groups by leveraging the trans-ethnic genetic similarity.

Briefings in bioinformatics·2026
Same author

Janus Nanofiber Membranes for Wearable Electronics: Integrated Conductivity, Unidirectional Water Transport, and Multimodal Responsiveness.

ACS applied materials & interfaces·2026

Related Experiment Video

Updated: Feb 2, 2026

Routine Screening Method for Microparticles in Platelet Transfusions
09:49

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

16.6K

Routine coagulation test abnormalities caused by rivaroxaban: A case report.

Zikai Song1, Haidi Wu, Hongyan Cao

  • 1Department of Cardiology, the First Hospital of Jilin University, Changchun, China.

Medicine
|November 9, 2018
PubMed
Summary

In some patients, rivaroxaban can alter coagulation tests like PT and aPTT, leading to bleeding. Coagulation monitoring may be necessary for elderly patients with kidney issues taking this anticoagulant.

More Related Videos

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo
06:23

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo

Published on: August 4, 2018

9.2K
Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes
12:24

Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes

Published on: June 3, 2014

12.7K

Related Experiment Videos

Last Updated: Feb 2, 2026

Routine Screening Method for Microparticles in Platelet Transfusions
09:49

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

16.6K
Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo
06:23

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo

Published on: August 4, 2018

9.2K
Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes
12:24

Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes

Published on: June 3, 2014

12.7K

Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Hematology

Background:

  • Rivaroxaban, a direct factor Xa inhibitor, is a widely used anticoagulant.
  • Current guidelines suggest routine coagulation monitoring is unnecessary for rivaroxaban therapy.
  • There is a need for clearer guidance on managing rivaroxaban in specific clinical scenarios.

Observation:

  • An 88-year-old male with atrial fibrillation presented with symptoms of gastrointestinal bleeding while on rivaroxaban.
  • The patient had moderate renal insufficiency (eGFR 46.7 mL/min).
  • Elevated prothrombin time (PT) and activated partial thromboplastin time (aPTT) were noted, suggesting rivaroxaban-induced bleeding.

Findings:

  • Discontinuation of rivaroxaban led to cessation of bleeding.
  • However, PT and aPTT remained abnormal for several days.
  • The patient subsequently experienced syncope and expired, highlighting potential delayed or persistent effects.

Implications:

  • This case suggests that some patients, particularly the elderly with renal impairment, may exhibit altered coagulation parameters (PT and aPTT) during rivaroxaban treatment.
  • Coagulation monitoring should be considered in high-risk patients to mitigate potential bleeding complications.
  • Clinical practice may require adjustments to current guidelines regarding monitoring for specific patient populations.