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Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...

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Updated: Jan 25, 2026

Isolation of Murine Intestinal Mesenchyme Resulting in a High Yield of Telocytes

Isolation of Murine Intestinal Mesenchyme Resulting in a High Yield of Telocytes

Published on: March 24, 2023

Extraskeletal Mesenchymal Chondrosarcoma.

Komal Arora, Nicole D Riddle¹

¹From the Department of Pathology, University of Texas Health Science Center, San Antonio. Dr Arora is now with the Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas. Dr Riddle is now with the Department of Pathology, Cunningham Pathology, Birmingham, Alabama.

Archives of Pathology & Laboratory Medicine

|November 9, 2018

Summary

This summary is machine-generated.

Extraskeletal mesenchymal chondrosarcoma is a rare soft tissue tumor. Diagnosis can be challenging, and prognosis varies by tumor location.

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Area of Science:

Oncology
Pathology
Soft Tissue Sarcomas

Background:

Extraskeletal mesenchymal chondrosarcoma is a rare malignancy.
Typically affects young adults (20-30s), with a slight female predominance.
Commonly found in the lower extremities, meninges, and orbits.

Purpose of the Study:

To describe the key features of extraskeletal mesenchymal chondrosarcoma.
To highlight diagnostic challenges, particularly in small biopsies.
To discuss the variable prognosis based on tumor location.

Main Methods:

Histopathological review of extraskeletal mesenchymal chondrosarcoma cases.
Analysis of clinical presentation and demographic data.
Correlation of tumor location with patient survival.

Main Results:

The tumor exhibits a characteristic biphasic pattern: small cells and hyaline cartilage.
Diagnostic difficulties arise when one component is absent in biopsy samples.
Prognosis is highly variable and significantly influenced by tumor site.

Conclusions:

Extraskeletal mesenchymal chondrosarcoma requires careful histopathological evaluation.
Awareness of potential diagnostic pitfalls is crucial for accurate diagnosis.
Tumor location is a critical factor in determining patient outcomes.