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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Update on Gastrointestinal Lymphomas.

Steven C Weindorf, Lauren B Smith, Scott R Owens1

  • 1From the Department of Pathology, University of Michigan, Ann Arbor.

Archives of Pathology & Laboratory Medicine
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PubMed
Summary

This review details specific gastrointestinal lymphomas, including monomorphic epitheliotropic intestinal T-cell lymphoma and Epstein-Barr virus-positive mucocutaneous ulcer. Definitions align with the 2016 World Health Organization classification for lymphoid neoplasms.

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Area of Science:

  • Gastroenterology and Hematology
  • Oncology
  • Pathology

Background:

  • Gastrointestinal lymphomas encompass a diverse group of lymphoid neoplasms.
  • Accurate classification is crucial for diagnosis and treatment.
  • The 2016 World Health Organization (WHO) classification provides updated criteria for lymphoid neoplasms.

Purpose of the Study:

  • To review and define key gastrointestinal lymphomas.
  • To highlight clinical, morphologic, and immunophenotypic features of these entities.
  • To align definitions with the latest WHO classification of lymphoid neoplasms.

Main Methods:

  • Review of selected gastrointestinal lymphoma entities.
  • Emphasis on clinical presentation.
  • Detailed morphologic and immunophenotypic analysis.
  • Adherence to the 2016 WHO classification of lymphoid neoplasms.

Main Results:

  • Detailed descriptions of monomorphic epitheliotropic intestinal T-cell lymphoma.
  • Characterization of indolent T-cell lymphoproliferative disorder of the gastrointestinal tract.
  • Overview of intestinal T-cell lymphoma, not otherwise specified.
  • Description of duodenal-type follicular lymphoma.
  • Focus on Epstein-Barr virus-positive mucocutaneous ulcer.

Conclusions:

  • The reviewed entities represent important categories within gastrointestinal lymphomas.
  • Understanding their distinct characteristics is vital for accurate diagnosis.
  • The 2016 WHO classification serves as the standard for these definitions.