A rare case of primary thyroid amyloidosis

Area of Science:

• Endocrinology
• Pathology

Background:

• Amyloid goiter involves amyloid deposition in the thyroid gland, leading to enlargement and compressive symptoms.
• This case involves a 45-year-old male with a neck swelling and mediastinal involvement.

Purpose of the Study:

• To present a case of amyloid goiter in a patient with a history of multiple myeloma.
• To highlight the diagnostic and therapeutic approach for amyloid goiter.

Main Methods:

• Clinical presentation of a neck swelling.
• Ultrasound imaging revealing an enlarged thyroid with mediastinal involvement.
• Histopathological examination of the removed thyroid gland.

Main Results:

• The patient presented with a large neck swelling.
• Ultrasound indicated a multinodular goiter with mediastinal extension.
• Histopathology confirmed diffuse amyloid deposition and metaplastic lipomatosis.

Conclusions:

• Amyloid goiter requires surgical management for symptom relief.
• Total thyroidectomy is the treatment of choice for amyloid goiter to alleviate compression symptoms.