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Helicobacter pylori outer membrane vesicles involvement in the infection development and Helicobacter pylori-related

Magdalena Chmiela1, Natalia Walczak1, Karolina Rudnicka2

  • 1Laboratory of Gastroimmunology, Department of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Łódź, Banacha 12/16, 90-237, Łódź, Poland.

Journal of Biomedical Science
|November 10, 2018
PubMed

Insights

Helicobacter pylori outer membrane vesicles (OMVs) deliver antigens and virulence factors, influencing host immune responses and disease progression in gastric infections. This review explores their critical role in H. pylori pathogenesis.

Area of Science:

  • Microbiology
  • Immunology
  • Gastroenterology

Background:

  • Helicobacter pylori (H. pylori) is implicated in gastritis, ulcers, and gastric cancer.
  • Outer membrane vesicles (OMVs) from H. pylori may mediate antigen transport and immune responses.

Purpose of the Study:

  • To review the biological significance of H. pylori OMVs.
  • To elucidate the role of H. pylori OMVs in infection pathogenesis and host responses.

Main Methods:

  • Literature review of studies on H. pylori OMVs.
  • Analysis of OMV composition and function.
  • Examination of OMV interactions with host cells and immune systems.

Main Results:

  • H. pylori OMVs carry virulence factors and antigens.
  • OMVs can internalize into host cells, affecting signaling and apoptosis.
  • OMVs modulate local and systemic inflammatory and immune responses.

Conclusions:

  • H. pylori OMVs are crucial in disease development.
  • OMVs contribute to H. pylori-associated pathologies by influencing host-pathogen interactions.
  • Understanding OMV roles is key to addressing H. pylori infections.
Keywords:
Helicobacter pylorigastritisinflammationouter membrane vesiclesvirulence factor

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