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Abdominal aortic calcification score can predict future coronary artery disease in hemodialysis patients: a 5-year

Hung-Chih Chen1, Wei-Ting Wang2, Chieh-Ning Hsi2

  • 1Division of Nephrology, Asia University Hospital, Taichung, Taiwan.

BMC Nephrology
|November 10, 2018
PubMed

Insights

Abdominal aortic calcification (AAC) score predicts future coronary artery disease (CAD) in hemodialysis patients. An AAC score above 5.5 indicates higher CAD risk, with age and diabetes as contributing factors.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Radiology

Background:

  • Abdominal aortic calcification (AAC) is linked to cardiovascular mortality in hemodialysis patients.
  • The association between AAC severity and future coronary artery disease (CAD) occurrence remains unclear.

Purpose of the Study:

  • To clarify the association between AAC severity and the occurrence of future CAD events in hemodialysis patients.

Main Methods:

  • Prospective cohort study of hemodialysis patients.
  • AAC severity quantified by AAC score using lateral lumbar radiography.
  • Receiver operating curve (ROC) analysis determined the cutoff AAC value for CAD prediction.

Main Results:

  • 303 patients followed for a median of 95 months.
  • Higher AAC scores observed in patients with new CAD events (9 vs. 5, p < 0.001).
  • Multivariate analysis showed AAC score as a predictor of CAD (HR 1.039, p=0.016); cutoff AAC score of 5.5 identified higher risk.

Conclusions:

  • AAC score effectively predicts future CAD events in hemodialysis patients.
  • An AAC score > 5.5 is a reliable marker for predicting CAD in end-stage renal disease (ESRD) patients.
  • Age, diabetes, prior CAD, and longer dialysis vintage are associated with higher AAC scores.
Abstract

Keywords:
Abdominal aortic calcificationCoronary artery diseaseHemodialysis

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