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Functional MRI in Atypical Parkinsonisms

Federica Agosta1, Elisabetta Sarasso2, Massimo Filippi3

  • 1Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

International Review of Neurobiology
|November 10, 2018
PubMed

Insights

Functional MRI (fMRI) reveals brain activity changes in atypical parkinsonisms like MSA and CBS, potentially enabling earlier diagnosis than structural scans. These findings aid in differential diagnosis and tracking disease progression.

Area of Science:

  • Neuroimaging
  • Neurology
  • Medical Diagnostics

Background:

  • Atypical parkinsonisms, including Multiple System Atrophy (MSA), Corticobasal Syndrome (CBS), and Progressive Supranuclear Palsy (PSP), present diagnostic challenges.
  • Functional MRI (fMRI) offers a non-invasive method to investigate brain function.

Purpose of the Study:

  • To review current knowledge on fMRI applications in atypical parkinsonisms.
  • To explore fMRI's potential for early diagnosis, differential diagnosis, disease monitoring, and therapeutic assessment.

Main Methods:

  • Review of resting-state functional connectivity studies.
  • Analysis of task-based brain activity alterations in patient cohorts.
  • Examination of longitudinal fMRI data.

Main Results:

  • Abnormal functional connectivity and task-based activity are evident in atypical parkinsonisms compared to healthy controls and Parkinson's disease.
  • Functional changes are detectable earlier than structural damage, suggesting diagnostic utility.
  • Limited longitudinal data indicates potential for tracking disease progression.

Conclusions:

  • fMRI shows promise in the early detection and differential diagnosis of atypical parkinsonisms.
  • fMRI may serve as a valuable tool for monitoring disease progression and evaluating treatment efficacy.
Keywords:
Atypical parkinsonismCorticobasal syndromeFunctional MRIMultiple system atrophyNetworkProgressive supranuclear palsy syndromeResting stateTask

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