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Related Experiment Video

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In Vitro Evaluation of The Effects Of Er,Cr:YSGG and Diode Lasers Used on Titanium Cylinder
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Iodine-supported titanium implants have good antimicrobial attachment effects.

Daisuke Inoue1, Tamon Kabata1, Yoshitomo Kajino1

  • 1Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Japan.

Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association
|November 10, 2018
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Iodine-supported titanium implants demonstrate significant antibacterial effects against common pathogens like MRSA and Pseudomonas aeruginosa. These innovative implants show great potential for preventing periprosthetic joint infections.

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Area of Science:

  • Biomaterials Science
  • Infectious Disease Research
  • Orthopedic Surgery

Background:

  • Previous research established iodine-supported titanium implants' efficacy against Methicillin-sensitive Staphylococcus aureus (MSSA).
  • Periprosthetic joint infections (PJI) can be caused by a diverse range of pathogens, including MRSA, Pseudomonas aeruginosa, MSSE, and fungi.
  • The study aimed to evaluate the broader antimicrobial efficacy of these implants against a wider spectrum of bacteria and fungi.

Purpose of the Study:

  • To assess the antibacterial attachment effects of iodine-supported titanium implants against Methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa (P. aeruginosa), Methicillin-sensitive Staphylococcus epidermidis (MSSE), and Candida albicans (C. albicans).
  • To determine if the developed implants are effective against a broader range of microorganisms implicated in periprosthetic joint infections.

Main Methods:

  • Three types of Ti-6Al-4V titanium plates were prepared: untreated (Ti), anodized with an oxide film (Ti-O), and treated with an iodine coating on the oxide film (Ti-I).
  • Antibacterial activity was evaluated using Japanese Industrial Standard (JIS) protocols, exposing implants to MRSA, P. aeruginosa, MSSE, and C. albicans.
  • Bacterial and fungal colonies were counted immediately after attachment and after 24 hours of incubation, with antibacterial activity values calculated based on JIS criteria.

Main Results:

  • The Ti-I surface showed no countable viable bacteria for any tested microorganism.
  • Significant differences in viable bacteria counts were observed between Ti-I and both Ti and Ti-O surfaces for all tested pathogens.
  • Antibacterial activity values for Ti-I exceeded 5.9 for MRSA, 2.8 for P. aeruginosa, 4.3 for MSSE, and 4.7 for C. albicans, all surpassing the JIS effective threshold of 2.0.

Conclusions:

  • Iodine-supported titanium implants exhibit potent antimicrobial attachment effects against MRSA, P. aeruginosa, MSSE, and C. albicans.
  • These implants demonstrate significant potential as advanced antibacterial solutions for preventing early-onset periprosthetic joint infections.
  • The findings support the clinical application of iodine-supported titanium implants in orthopedic surgery to mitigate infection risks.