Related Experiment Video

Updated: Feb 2, 2026

In Vitro Evaluation of The Effects Of Er,Cr:YSGG and Diode Lasers Used on Titanium Cylinder
07:05

In Vitro Evaluation of The Effects Of Er,Cr:YSGG and Diode Lasers Used on Titanium Cylinder

Published on: June 6, 2025

574

Iodine-supported titanium implants have good antimicrobial attachment effects

Daisuke Inoue1, Tamon Kabata1, Yoshitomo Kajino1

  • 1Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Japan.

Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association
|November 10, 2018
PubMed
Abstract

Insights

Iodine-supported titanium implants demonstrate significant antibacterial effects against common pathogens like MRSA and Pseudomonas aeruginosa. These innovative implants show great potential for preventing periprosthetic joint infections.

Area of Science:

  • Biomaterials Science
  • Infectious Disease Research
  • Orthopedic Surgery

Background:

  • Previous research established iodine-supported titanium implants' efficacy against Methicillin-sensitive Staphylococcus aureus (MSSA).
  • Periprosthetic joint infections (PJI) can be caused by a diverse range of pathogens, including MRSA, Pseudomonas aeruginosa, MSSE, and fungi.
  • The study aimed to evaluate the broader antimicrobial efficacy of these implants against a wider spectrum of bacteria and fungi.

Purpose of the Study:

  • To assess the antibacterial attachment effects of iodine-supported titanium implants against Methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa (P. aeruginosa), Methicillin-sensitive Staphylococcus epidermidis (MSSE), and Candida albicans (C. albicans).
  • To determine if the developed implants are effective against a broader range of microorganisms implicated in periprosthetic joint infections.

Main Methods:

  • Three types of Ti-6Al-4V titanium plates were prepared: untreated (Ti), anodized with an oxide film (Ti-O), and treated with an iodine coating on the oxide film (Ti-I).
  • Antibacterial activity was evaluated using Japanese Industrial Standard (JIS) protocols, exposing implants to MRSA, P. aeruginosa, MSSE, and C. albicans.
  • Bacterial and fungal colonies were counted immediately after attachment and after 24 hours of incubation, with antibacterial activity values calculated based on JIS criteria.

Main Results:

  • The Ti-I surface showed no countable viable bacteria for any tested microorganism.
  • Significant differences in viable bacteria counts were observed between Ti-I and both Ti and Ti-O surfaces for all tested pathogens.
  • Antibacterial activity values for Ti-I exceeded 5.9 for MRSA, 2.8 for P. aeruginosa, 4.3 for MSSE, and 4.7 for C. albicans, all surpassing the JIS effective threshold of 2.0.

Conclusions:

  • Iodine-supported titanium implants exhibit potent antimicrobial attachment effects against MRSA, P. aeruginosa, MSSE, and C. albicans.
  • These implants demonstrate significant potential as advanced antibacterial solutions for preventing early-onset periprosthetic joint infections.
  • The findings support the clinical application of iodine-supported titanium implants in orthopedic surgery to mitigate infection risks.

More Related Videos

Imaging Cell Viability on Non-transparent Scaffolds — Using the Example of a Novel Knitted Titanium Implant07:28

Imaging Cell Viability on Non-transparent Scaffolds — Using the Example of a Novel Knitted Titanium Implant

Published on: September 7, 2016

11.9K
Quantifying the Effects of Antimicrobials on In vitro Biofilm Architecture using COMSTAT Software06:18

Quantifying the Effects of Antimicrobials on In vitro Biofilm Architecture using COMSTAT Software

Published on: December 14, 2020

4.1K

Related Concept Videos

Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
994
Attachment01:20

Attachment

Attachment is vital for infant development, as warm social interactions support growth and well-being. In a classic 1958 study by Harry Harlow, the significance of warmth and comfort in forming attachments was examined. Harlow separated newborn monkeys from their mothers and provided two artificial "mothers": one made of cold wire and the other covered in soft cloth. Despite the wire mother offering food, the infant monkeys preferred the comfort of the cloth mother, demonstrating that...
522
Theory of Romantic Attachment in Adulthood03:34

Theory of Romantic Attachment in Adulthood

Attachment is a long-standing connection or bond with others. While Attachment Theory was conceived in developmental psychology to describe infant-caregiver bonding, it's been extended into adulthood to include romantic relationships. 
50.0K
Self-Help Support Groups01:28

Self-Help Support Groups

Self-help support groups are voluntary, community-based organizations that provide a platform for individuals with shared concerns to exchange support, insights, and practical strategies for coping with life challenges. Typically led by group members or paraprofessionals, these groups form a cornerstone of mental health care, especially in reaching populations that are underserved by traditional healthcare systems.
Accessibility and Cost-Effectiveness
One of the primary strengths of self-help...
352
Attachment Styles01:24

Attachment Styles

Jeffrey Simpson's attachment theory suggests that early caregiver relationships shape lasting patterns of behavior and emotional regulation, known as attachment styles. These patterns are organized along two key dimensions: self-esteem and interpersonal trust. The intersection of these dimensions produces four primary attachment styles that typically persist throughout life and significantly influence how individuals form and maintain relationships.Secure Attachment StyleIndividuals with a...
432
Attachment of Sister Chromatids02:57

Attachment of Sister Chromatids

As cells progress into mitosis, the nuclear envelope breaks down, and the condensed chromosomes are exposed to the array of bipolar microtubules of the mitotic spindle. The kinetochore, a large, disc-shaped protein complex, is present at the centromere region of the sister chromatids and acts as a binding site for the microtubules.  Usually, the plus-end of a single microtubule is embedded within the kinetochore. However, some kinetochores first establish lateral contact with the side-wall...
4.1K