Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

1.7K
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
1.7K
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

939
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
939
Self-Help Support Groups01:28

Self-Help Support Groups

352
Self-help support groups are voluntary, community-based organizations that provide a platform for individuals with shared concerns to exchange support, insights, and practical strategies for coping with life challenges. Typically led by group members or paraprofessionals, these groups form a cornerstone of mental health care, especially in reaching populations that are underserved by traditional healthcare systems.
Accessibility and Cost-Effectiveness
One of the primary strengths of self-help...
352
Stages of Sleep01:22

Stages of Sleep

1.4K
Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
1.4K
Understanding Sleep01:11

Understanding Sleep

1.6K
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
1.6K
Sleep Apnea01:21

Sleep Apnea

567
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
567

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Central Nucleus of the Amygdala Encodes the Motivation to Pursue Ethanol.

bioRxiv : the preprint server for biology·2026
Same author

Adaptive communication between cell assemblies and "reader" neurons shapes flexible brain dynamics.

PLoS biology·2025
Same author

Large sharp-wave ripples promote hippocampo-cortical memory reactivation and consolidation during sleep.

Neuron·2025
Same author

Ventral Hippocampus Modulates Prefrontal Control of Background Contextual Fear After Cued Extinction.

The European journal of neuroscience·2025
Same author

Large sharp-wave ripples promote hippocampo-cortical memory reactivation and consolidation.

bioRxiv : the preprint server for biology·2025
Same author

Rapid emergence of latent knowledge in the sensory cortex drives learning.

Nature·2025

Related Experiment Video

Updated: Feb 2, 2026

Nest Building Behavior as an Early Indicator of Behavioral Deficits in Mice
06:11

Nest Building Behavior as an Early Indicator of Behavioral Deficits in Mice

Published on: October 19, 2019

21.2K

Nested sequences of hippocampal assemblies during behavior support subsequent sleep replay.

Céline Drieu1, Ralitsa Todorova1, Michaël Zugaro2

  • 1Center for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, PSL Research University, Paris, France.

Science (New York, N.Y.)
|November 10, 2018
PubMed
Summary

During wakefulness, active movement is crucial for forming memories. Theta sequences, essential for memory encoding, are impaired by passive travel, hindering subsequent sleep consolidation.

More Related Videos

Assessing Burrowing, Nest Construction, and Hoarding in Mice
08:23

Assessing Burrowing, Nest Construction, and Hoarding in Mice

Published on: January 5, 2012

33.1K
Polygraphic Recording Procedure for Measuring Sleep in Mice
08:45

Polygraphic Recording Procedure for Measuring Sleep in Mice

Published on: January 25, 2016

25.3K

Related Experiment Videos

Last Updated: Feb 2, 2026

Nest Building Behavior as an Early Indicator of Behavioral Deficits in Mice
06:11

Nest Building Behavior as an Early Indicator of Behavioral Deficits in Mice

Published on: October 19, 2019

21.2K
Assessing Burrowing, Nest Construction, and Hoarding in Mice
08:23

Assessing Burrowing, Nest Construction, and Hoarding in Mice

Published on: January 5, 2012

33.1K
Polygraphic Recording Procedure for Measuring Sleep in Mice
08:45

Polygraphic Recording Procedure for Measuring Sleep in Mice

Published on: January 25, 2016

25.3K

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Memory Research

Background:

  • Memory consolidation during sleep involves replay of neuronal activity.
  • The role of network dynamics during initial memory storage (encoding) during wakefulness remains unclear.
  • Both slow and fast (theta) timescale neuronal sequences are implicated in memory formation.

Purpose of the Study:

  • To investigate the role of theta timescale sequences in the initial formation of memory traces during wakefulness.
  • To determine if active versus passive experience affects neuronal sequence replay and subsequent memory consolidation.
  • To test the hypothesis that nested neuronal sequences are critical for memory encoding.

Main Methods:

  • Electrophysiological recordings of place cell activity in rats.
  • Manipulating behavioral states (passive travel vs. active running on a treadmill) during memory encoding.
  • Analyzing neuronal sequence activity on behavioral and theta timescales.
  • Assessing subsequent sleep replay and memory consolidation.

Main Results:

  • Passive travel on a model train degraded theta sequences in place cells, impairing sleep replay.
  • Active running on a treadmill during transport preserved theta sequences and accurate trajectory replay during sleep.
  • Behavioral timescale sequences were present in both conditions, but theta sequences were critical.

Conclusions:

  • Theta timescale sequences, nested within slower sequences, are instrumental for the initial formation of memory traces.
  • Active engagement during experience is necessary for generating theta sequences crucial for memory encoding.
  • These findings support the role of specific neuronal dynamics during wakefulness in preparing memories for sleep-dependent consolidation.