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Angiotensin II Brings More Questions Than Answers
P & T : a Peer-Reviewed Journal for Formulary Management
|November 10, 2018
Summary
Synthetic human angiotensin II (ATII) offers a new treatment for distributive shock, improving blood pressure in patients. However, concerns regarding safety, efficacy, and cost-effectiveness require careful consideration for clinical implementation.
Area of Science:
- Pharmacology
- Critical Care Medicine
- Cardiovascular Research
Background:
- Synthetic human angiotensin II (ATII) was approved by the FDA in December 2017.
- ATII provides a novel therapeutic option for managing distributive shock.
Purpose of the Study:
- To examine the controversies surrounding the safety and efficacy of ATII.
- To discuss the cost-effectiveness of implementing ATII in clinical practice.
Main Methods:
- Analysis of the ATHOS-3 trial results.
- Review of safety concerns, including thrombotic and infectious complications.
- Evaluation of cost implications for ATII acquisition.
Main Results:
- Patients receiving ATII were more likely to achieve target mean arterial pressure (MAP) compared to placebo.
- The ATHOS-3 trial identified potential thrombotic and infectious complications associated with ATII use.
- The acquisition cost of ATII is approximately $1,500 per vial.
Conclusions:
- ATII presents a new treatment modality for distributive shock with demonstrated efficacy in improving MAP.
- Clinicians must weigh the benefits of ATII against its associated safety risks and high cost.
- Further evaluation is needed to optimize the cost-effective implementation of ATII in patient care.
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