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Advances in antitumor effects of NSAIDs

Zhen Zhang1,2, Fulin Chen1,2, Lijun Shang1,2,3

  • 1Laboratory of Tissue Engineering, Faculty of Life Science, Northwest University, Xi'an, Shaanxi Province 710069, People's Republic of China, lijunshang@hotmail.com, chenfl@nwu.edu.cn.

Cancer Management and Research
|November 10, 2018
PubMed

Insights

Nonsteroidal anti-inflammatory drugs (NSAIDs), particularly aspirin, show promise in cancer prevention and treatment. Further research is needed to clarify the exact mechanisms by which NSAIDs prevent tumor development.

Area of Science:

  • Oncology
  • Pharmacology
  • Preventive Medicine

Background:

  • Growing evidence supports the use of nonsteroidal anti-inflammatory drugs (NSAIDs) for cancer prevention and treatment.
  • Guidelines now recommend NSAIDs, especially aspirin, for primary prevention of cardiovascular disease and colorectal cancer.
  • The precise mechanisms underlying NSAID-mediated cancer prevention remain unclear.

Purpose of the Study:

  • To summarize recent advancements in the application of NSAIDs, with a focus on aspirin, for tumor prevention and treatment.
  • To discuss emerging ideas and future research directions in this field.

Main Methods:

  • Literature review of recent studies on NSAIDs and cancer.
  • Analysis of guidelines and recommendations regarding NSAID use in cancer prevention.
  • Discussion of current hypotheses and proposed mechanisms.

Main Results:

  • NSAIDs, particularly aspirin, have demonstrated significant roles in cancer prevention, notably for colorectal cancer.
  • Established guidelines acknowledge the preventive potential of aspirin for specific cancers.
  • The exact molecular pathways and biological effects of NSAIDs in cancer prevention require further elucidation.

Conclusions:

  • NSAIDs, especially aspirin, represent a promising strategy for cancer prevention and potentially treatment.
  • Further investigation into the mechanisms of action is crucial for optimizing NSAID-based cancer therapies.
  • Future research should focus on elucidating these mechanisms to develop more targeted and effective cancer prevention and treatment approaches.
Keywords:
NSAIDsaspirincancerplatelets

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