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A stereoselective sequential organocascade and multicomponent approach for the preparation of tetrahydropyridines and
Radell Echemendía1, Gustavo P da Silva, Meire Y Kawamura
1Center of Excellence for Research in Sustainable Chemistry (CERSusChem), Department of Chemistry, Federal University of São Carlos - UFSCar, Rodovia Washington Luís, km 235, SP-310, São Carlos, São Paulo 13565-905, Brazil. mwpaixao@ufscar.br marco.ferreira@ufscar.br.
Abstract:
A stereoselective multicomponent approach leading to a novel class of pentasubstituted tetrahydropyridines is described. Variation of the components enabled the incorporation of peptide, sugar and steroid moieties to access chimeric derivatives. DFT calculations provide insights about the unprecedented high diastereoselectivity of the MCR.
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