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Identification of Differentially Expressed Genes under the Regulation of Transcription Factors in Osteosarcoma

Yang Liu1, Jianzhong Guan2, Xiaotian Chen1

  • 1Department of Orthopaedics, The First Affiliated Hospital of Bengbu Medical College, No. 287, ChangHuai Road, Bengbu, 233004, Anhui Province, China.

Pathology Oncology Research : POR
|November 10, 2018
PubMed

Keywords:
Differentialy expressed genesMicroarray datasetOsteosarcomaTranscription factors

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Transcription Factors

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Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
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