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Updated: Feb 2, 2026

Event-related Potentials During Target-response Tasks to Study Cognitive Processes of Upper Limb Use in Children with Unilateral Cerebral Palsy
08:26

Event-related Potentials During Target-response Tasks to Study Cognitive Processes of Upper Limb Use in Children with Unilateral Cerebral Palsy

Published on: January 11, 2016

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Development of hand function during the first year of life in children with unilateral cerebral palsy

Leanne Sakzewski1, Elisa Sicola2, Cornelia H Verhage3

  • 1Queensland Cerebral Palsy and Rehabilitation Research Centre, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

Developmental Medicine and Child Neurology
|November 10, 2018
PubMed

Insights

Three developmental trajectories for infant hand function in unilateral cerebral palsy (CP) were identified. A low-functioning group showed minimal progress, with early impairment strongly predicting trajectory. Early intervention is key for improving hand function in infants with CP.

Area of Science:

  • Pediatrics
  • Neurology
  • Developmental Science

Background:

  • Unilateral cerebral palsy (CP) affects hand function in infants.
  • Understanding developmental trajectories is crucial for early intervention and prognosis.

Purpose of the Study:

  • To identify distinct developmental trajectories of hand function in infants aged 3 to 12 months with unilateral CP.
  • To explore factors associated with different developmental paths.

Main Methods:

  • Recruited infants at high risk for unilateral CP from multiple countries.
  • Utilized the Hand Assessment for Infants (HAI) for serial assessments up to 12 months.
  • Applied group-based trajectory modeling to identify developmental subgroups.

Main Results:

  • Identified three trajectories: low-functioning (46%), moderate-functioning (31%), and high-functioning (23%).
  • The degree of hand impairment at 6 months strongly predicted trajectory group membership.
  • No significant associations found between demographic variables or intervention type and trajectory group.

Conclusions:

  • Three distinct hand function development trajectories exist for infants with unilateral CP.
  • Early hand impairment is a significant predictor of long-term function.
  • The Hand Assessment for Infants (HAI) effectively captures developmental changes over the first year.
Abstract

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