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Serum pentraxin-3 levels and flow-mediated dilation in dipper and non-dipper hypertension

Çağlar Alp1, Mehmet Tolga Dogru1, Muhammed Karadeniz1

  • 1Faculty of Medicine, Department of Cardiology, Kırıkkale University, Kirikkale, Turkey.

Journal of Clinical Laboratory Analysis
|November 10, 2018
PubMed

Insights

Serum pentraxin-3 (PTX3) levels are higher in non-dipper hypertension patients and correlate with impaired endothelial function. This suggests PTX3 may indicate hypertension-related vascular damage.

Area of Science:

  • Cardiovascular Research
  • Biomarker Discovery
  • Hypertension Pathophysiology

Background:

  • Endothelial dysfunction is a key process in hypertension.
  • Serum pentraxin-3 (PTX3) is a potential diagnostic and prognostic biomarker.
  • Investigating PTX3 in relation to endothelial function in hypertension is of significant interest.

Purpose of the Study:

  • To examine the association between serum PTX3 levels and endothelial function, measured by flow-mediated dilation (FMD).
  • To compare serum PTX3 levels and FMD in dipper and non-dipper hypertensive patients.

Main Methods:

  • Included 90 hypertensive patients, categorized into dipper (n=38) and non-dipper (n=52) groups using 24-hour ambulatory blood pressure monitoring.
  • Assessed endothelial function noninvasively using the flow-mediated dilation (FMD) method.

Main Results:

  • Serum PTX3 levels were significantly higher in non-dipper hypertension patients compared to dipper patients (P=0.028).
  • A negative correlation was observed between serum PTX3 levels and the FMD basal/FMD hyperemia ratio (r=-0.297, P=0.05).

Conclusions:

  • Serum PTX3 levels are closely linked to indirect noninvasive measures of endothelial function (FMD).
  • Findings suggest PTX3 may serve as a relevant biomarker for endothelial dysfunction in both dipper and non-dipper hypertension.
Abstract

Keywords:
ambulatory blood pressure monitoringdipper hypertensionflow-mediated dilationnon-dipper hypertensionpentraxin-3

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