Tpeak-Tend/QT interval predicts ST-segment resolution and major adverse cardiac events in acute ST-segment elevation...

Area of Science:

• Cardiology
• Electrophysiology
• Medical Diagnostics

Background:

• Elevated ST-segment and Tpeak-Tend (Tp-e) interval are known predictors of major adverse cardiac events (MACEs) in ST-segment elevation myocardial infarction (STEMI).
• The relationship between ST-segment resolution (STR) and Tp-e interval during percutaneous coronary intervention (PCI) requires further elucidation.

Purpose of the Study:

• To investigate the electrophysiologic relationship between ST-segment resolution (STR) and Tpeak-Tend (Tp-e) interval parameters in STEMI patients undergoing PCI.
• To determine the predictive value of Tp-e interval and its ratio to QT interval (Tp-e/QT) for STR and MACEs.

Main Methods:

• Prospective evaluation of STEMI patients admitted to the hospital.
• Measurement and analysis of ST-segment resolution (STR), Tp-e interval, corrected Tp-e interval (Tp-ec), and Tp-e/QT ratio post-PCI.
• Multivariate analysis and receiver operating characteristic (ROC) curve analysis to identify predictors of STR and MACEs.

Main Results:

• Both Tp-ec interval and Tp-e/QT ratio were significantly elevated in STEMI patients and partially recovered post-PCI.
• Patients with incomplete STR (ISTR) exhibited higher Tp-ec and Tp-e/QT ratios compared to those with complete STR (CSTR) post-PCI.
• The Tp-e/QT ratio was identified as an independent and strongest predictor for STR in multivariate and ROC analyses.

Conclusions:

• ST-segment resolution (STR) and changes in Tp-e parameters are significant predictors of arrhythmias and MACEs in STEMI patients following PCI.
• The Tp-e/QT ratio serves as a valuable prognostic marker for predicting STR and MACEs in STEMI patients post-PCI.