Related Experiment Video

Updated: Feb 2, 2026

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

1.5K

Right ventricular dysfunction and remodeling in diabetic cardiomyopathy

Yin Kang1,2, Sheng Wang1,3, Jiapeng Huang4

  • 1Department of Anesthesiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences , Guangzhou , China.

American Journal of Physiology. Heart and Circulatory Physiology
|November 10, 2018
PubMed

Insights

Diabetic cardiomyopathy (DCM) affects the right ventricle (RV) more than previously known. This review explores RV dysfunction mechanisms, diagnosis, and treatment strategies for better patient outcomes.

Area of Science:

  • Cardiology
  • Endocrinology
  • Pathophysiology

Background:

  • Diabetic cardiomyopathy (DCM) is a growing global health concern.
  • Left ventricular (LV) dysfunction in DCM is recognized, but right ventricular (RV) involvement is less understood.
  • RV dysfunction shares some mechanisms with LV dysfunction, like insulin resistance and oxidant injury, but has unique properties.

Purpose of the Study:

  • To review the mechanisms of RV dysfunction in DCM.
  • To discuss imaging approaches for early detection and intervention.
  • To highlight the need for further research in RV and pulmonary vascular function in DCM.

Main Methods:

  • Literature review of mechanisms and pathophysiology of RV dysfunction in DCM.
  • Review of current and emerging imaging techniques for RV assessment.
  • Analysis of potential therapeutic strategies.

Main Results:

  • RV dysfunction in DCM is complex, influenced by unique RV properties and pulmonary hemodynamics.
  • Insulin resistance and oxidant injury are implicated pathways.
  • Early detection and intervention strategies are crucial but require more data.

Conclusions:

  • RV dysfunction is a significant, under-recognized complication of DCM.
  • Further research using animal models and clinical trials is essential.
  • Improved understanding and treatment of RV dysfunction can enhance clinical outcomes in DCM patients.

Keywords:
cardiac magnetic resonancediabetic cardiomyopathyechocardiographypulmonary hypertensionreactive oxygen speciesright heart failureright ventricular remodeling

More Related Videos

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model05:58

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Published on: April 18, 2025

649
Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine10:08

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine

Published on: February 17, 2018

14.0K

Related Concept Videos

Nucleosome Remodeling02:54

Nucleosome Remodeling

Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
11.2K
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
568
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
490
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
538
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
442
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
605