Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

18.6K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
18.6K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

9.9K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.9K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.7K
3.7K
Epigenetic Regulation01:46

Epigenetic Regulation

33.8K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.8K
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

7.7K
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.7K
Small interfering RNAs (siRNA)02:30

Small interfering RNAs (siRNA)

4.5K
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Loss of lncRNA <i>H19</i> impairs neonatal cardiac regeneration.

American journal of physiology. Cell physiology·2026
Same author

RNA splicing and cardiovascular disease: a guide for cardiologists.

European heart journal·2026
Same author

Analysis of metabolic rewiring in MDR1-overexpressing drug-resistant glioblastoma.

Frontiers in pharmacology·2026
Same author

Multi-Environment Evaluation and Stability Analysis for the Selection of Elite Pearl Millet Genotypes with Better Fodder Yield and Quality Component Traits.

Plants (Basel, Switzerland)·2026
Same author

Enhancing hybridization potential through standardizing emasculation techniques and molecular marker integration in finger millet (Eleusine coracana L.).

Plant methods·2026
Same author

Evolutionary-guided advanced deep-learning architecture powers mammalian GPCRome agonist predictions.

Cell reports·2026
Same journal

Clinical Utility of Single Ventricular Stroke Work Index for Predicting Prognosis in Patients with Functional Single Ventricle.

American journal of physiology. Heart and circulatory physiology·2026
Same journal

Sex-Specific Responses in the Early Stages of Diet-Induced Cardiovascular-Kidney-Metabolic Syndrome.

American journal of physiology. Heart and circulatory physiology·2026
Same journal

The R120G Knock-in Mutation in αB-Crystallin is Insufficient to Induce Cardiomyopathy in Mice.

American journal of physiology. Heart and circulatory physiology·2026
Same journal

Interplay of Oxidative Stress and Inflammatory Mechanisms in Doxorubicin-induced Cardiomyopathy.

American journal of physiology. Heart and circulatory physiology·2026
Same journal

Impact of moderate isocapnic hyperthermia on dynamic cerebral autoregulation and its directional sensitivity.

American journal of physiology. Heart and circulatory physiology·2026
Same journal

Repetitive Pressure Overload; Species Disparities, Mechanisms and Translational Relevance.

American journal of physiology. Heart and circulatory physiology·2026
See all related articles

Related Experiment Video

Updated: Feb 2, 2026

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

9.3K

Noncoding RNAs: potential regulators in cardioncology.

Shambhabi Chatterjee1, Shashi Kumar Gupta1, Christian Bär1

  • 1Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School , Hannover , Germany.

American Journal of Physiology. Heart and Circulatory Physiology
|November 10, 2018
PubMed
Summary
This summary is machine-generated.

Cancer therapies increase cardiovascular risks. Noncoding RNAs (ncRNAs) are crucial in both cancer and heart failure, but their role in cardioncology is understudied. This review explores ncRNAs in cardioncology, including therapeutic potential.

Keywords:
biomarkercardiotoxicitydoxorubicinheart failurenoncoding RNA

More Related Videos

Isolation of Small Noncoding RNAs from Human Serum
06:44

Isolation of Small Noncoding RNAs from Human Serum

Published on: June 19, 2014

18.6K
Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data
07:35

Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data

Published on: December 1, 2023

1.2K

Related Experiment Videos

Last Updated: Feb 2, 2026

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

9.3K
Isolation of Small Noncoding RNAs from Human Serum
06:44

Isolation of Small Noncoding RNAs from Human Serum

Published on: June 19, 2014

18.6K
Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data
07:35

Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data

Published on: December 1, 2023

1.2K

Area of Science:

  • Cardioncology
  • Genomics
  • Molecular Biology

Background:

  • Cancer survivorship is increasing due to advances in diagnosis and treatment.
  • Cancer therapies can cause significant cardiovascular complications, leading to cardiotoxicity and other heart conditions.
  • Cardioncology is an emerging field focused on the intersection of cancer and cardiovascular disease.

Purpose of the Study:

  • To review current knowledge on noncoding RNAs (ncRNAs) in cardioncology.
  • To explore the role of ncRNAs in the interplay between cancer and cardiovascular disorders.
  • To discuss therapeutic strategies and translational applications of ncRNAs in cardioncology.

Main Methods:

  • Literature review of existing research on ncRNAs in cancer and cardiovascular diseases.
  • Analysis of the role of ncRNAs as regulators of gene expression in both conditions.
  • Synthesis of current findings to identify knowledge gaps and future directions in cardioncology.

Main Results:

  • Noncoding RNAs (ncRNAs) are key regulators of gene expression implicated in both cancer and heart failure.
  • Limited research currently exists on the specific role of ncRNAs within the field of cardioncology.
  • ncRNAs show potential as biomarkers and therapeutic targets for managing cardiotoxicity in cancer survivors.

Conclusions:

  • Noncoding RNAs (ncRNAs) represent a promising area of research in cardioncology.
  • Further investigation into ncRNAs could lead to novel diagnostic and therapeutic strategies for cancer patients at risk of heart disease.
  • Translational applications of ncRNAs may improve cardiovascular outcomes for cancer survivors.