Related Experiment Video
Updated: Feb 2, 2026
06:48
An Orthotopic Murine Model of Human Prostate Cancer Metastasis
Published on: September 18, 2013
35.9K
Macro-CK type 2 in metastatic prostate cancer.
Abass Eidizadeh1, Nicolas von Ahsen2, Steffen Friedewald3
1Universitätsmedizin Göttingen, Georg-August-Universität Göttingen, Institut für Klinische Chemie, Robert-Koch-Str. 40, 37075 Göttingen, Germany, Phone: 0551 39-8549.
Diagnosis (Berlin, Germany)
|November 10, 2018
Summary
Creatine kinase muscle/brain (CK-MB) aids heart vs. skeletal muscle diagnosis. A case study highlights macro-CK type 2, often linked to cancer, as a diagnostic pitfall.
Area of Science:
- Biochemistry
- Clinical Diagnostics
- Oncology
Background:
- Creatine kinase muscle/brain (CK-MB) is crucial for diagnosing elevated creatine kinase levels.
- Differentiating cardiac from skeletal muscle origins of CK elevations is essential.
- Understanding diagnostic pitfalls in CK-MB interpretation is necessary.
Observation:
- A 75-year-old patient with metastatic castration-resistant prostate cancer presented with diagnostic challenges.
- Macro-CK type 2 was identified in this patient.
- Isoenzyme electrophoresis was used for identification.
Findings:
- Macro-CK type 2 can mimic or complicate CK-MB interpretation.
- This specific macro-CK variant is often associated with malignancies.
- The case highlights a potential diagnostic pitfall in CK-MB testing.
Implications:
- Awareness of macro-CK type 2 is vital for accurate CK-MB interpretation in cancer patients.
- Isoenzyme electrophoresis can aid in identifying this diagnostic pitfall.
- This finding may influence diagnostic strategies for CK elevations in oncology.
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