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Urinary proteomic biomarkers in oncology: ready for implementation?
Maria Frantzi1, Agnieszka Latosinska1, Iwona Belczacka1
1a Research and Development , Mosaiques Diagnostics GmbH , Hannover , Germany.
Expert Review of Proteomics
|November 10, 2018
Summary
Urinary protein biomarkers show promise for early cancer detection and predicting treatment response. Multi-marker approaches are key for clinical implementation, especially for bladder cancer and cholangiocarcinoma.
Area of Science:
- Oncology
- Biochemistry
- Clinical Diagnostics
Background:
- Biomarkers are crucial for improving cancer patient management through early detection and response prediction.
- Proteins, reflecting molecular phenotypes, are valuable biomarkers and therapeutic targets.
- The urinary proteome offers a readily accessible source for biomarker discovery, with some proteins already in clinical use.
Purpose of the Study:
- To review the literature on urine proteins and proteome analysis in oncology over the past five years.
- To provide an overview of the current status of urine protein and peptide biomarkers.
- To emphasize the clinical utility and implementation potential of these biomarkers.
Main Methods:
- Literature review of studies published within the last five years.
- Focus on urine protein and proteome analysis in cancer research.
- Emphasis on biomarkers with demonstrated clinical value.
Main Results:
- Several urine protein biomarkers show potential for clinical implementation, particularly for bladder cancer and cholangiocarcinoma, often utilizing multi-marker strategies.
- Numerous biomarkers have been identified in studies with limited statistical power.
- Consistent reporting of certain biomarkers across multiple studies highlights their potential.
Conclusions:
- Multi-marker classifiers are anticipated to be the primary route for clinical implementation of urinary biomarkers.
- Further validation through robust confirmatory and prospective studies is essential for consistently reported biomarkers.
- Urinary proteome analysis holds significant promise for advancing cancer diagnostics and personalized medicine.
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