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Updated: Feb 2, 2026

Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents
Published on: June 10, 2013
Risk analysis of suicidal ideations and postpartum depression with antenatal alpha methyldopa use
Ajita S Nayak1, Hrishikesh B Nachane1
1Department of Psychiatry, Seth GS Medical College, KEM Hospital, Acharya Donde Marg, Parel, Mumbai, 400012, India.
Abstract:
Out of the various risk factors for postpartum depression, use of pharmacotherapy during pregnancy is the most poorly understood. The present study aimed to establish risk of postpartum depression and suicidal ideations with antenatal use of alpha methyldopa. Out of the 100 postpartum women assessed, 77.78% of the women who were prescribed alpha methyldopa had significant postpartum depression. There was statistically significant risk of postpartum depression associated with alpha methyldopa (p = 0.026, OR = 6.45). There was no increased suicidal risk with use of alpha methyldopa in these women (p = 1.00).
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