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Relation of Platelet Parameters With Incident Cardiovascular Disease (The Dongfeng-Tongji Cohort Study)
Shiqi He1, Wenhui Lei1, Jun Li2
1Department of Occupational and Environmental Health and Ministry of Education Key Lab for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Insights
Lower platelet count (PLT) and mean platelet volume (MPV) correlate with reduced stroke risk. Lower MPV and platelet distribution width (PDW) are linked to decreased cardiovascular disease (CVD) and coronary heart disease (CHD) risk.
Area of Science:
- Cardiovascular Medicine
- Hematology
- Epidemiology
Background:
- Prospective studies on platelet count (PLT), mean platelet volume (MPV), and platelet distribution width (PDW) in relation to incident cardiovascular disease (CVD) are limited.
- Understanding these associations is crucial for cardiovascular risk assessment, particularly in aging populations.
Purpose of the Study:
- To investigate the prospective relationships between PLT, MPV, PDW, and incident CVD, coronary heart disease (CHD), and stroke.
- To analyze these associations in a large cohort of middle-aged and older Chinese adults.
Main Methods:
- A prospective cohort study involving 31,751 participants free of major diseases at baseline.
- Median follow-up of 5.9 years identified 5,683 incident CVD cases (4,423 CHD, 1,260 stroke).
- Cox proportional hazard models were employed to calculate hazard ratios (HRs) and 95% confidence intervals (CIs).
Main Results:
- Lower PLT (< 146 10E9/L) was associated with a reduced risk of incident stroke (adjusted HR: 0.80; 95% CI: 0.68 to 0.95).
- Lower MPV (< 7.3 fl) was linked to decreased risks of incident CVD (HR: 0.81; 95% CI: 0.75 to 0.88), CHD (HR: 0.80; 95% CI: 0.73 to 0.88), and stroke (HR: 0.84; 95% CI: 0.71 to 1.00).
- Lower PDW (< 13.2 %) was associated with reduced risks of incident CVD (HR: 0.80; 95% CI: 0.73 to 0.87) and CHD (HR: 0.78; 95% CI: 0.70 to 0.86).
Conclusions:
- Lower platelet count and mean platelet volume are significantly associated with a lower risk of stroke.
- Lower mean platelet volume and platelet distribution width are significantly associated with lower risks of cardiovascular disease and coronary heart disease.
Abstract:
Prospective studies on the relations between platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and incident cardiovascular disease (CVD) were still limited. This study aimed to investigate the above-mentioned prospective relations in the middle-aged and older Chinese populations based on the Dongfeng-Tongji cohort. We included 31,751 participants who were free of coronary heart disease (CHD), stroke, cancer, or severely abnormal electrocardiogram at baseline. During a median follow-up of 5.9 years, we identified 5,683 incident CVD cases, including 4,423 CHD and 1,260 stroke cases. Cox proportional hazard models were used to estimate the hazard ratios (HRs) and 95% confident intervals (CIs) for the relation analyses. Compared with participants with 146 ≤ PLT ≤ 233 10E9/L, the adjusted HR (95% CI) of those with PLT < 146 10E9/L was 0.80 (0.68 to 0.95) for incident stroke. Compared with participants with 7.3 ≤ MPV ≤ 10.3 fl, the adjusted HRs (95% CIs) of those with MPV < 7.3 fl were 0.81 (0.75 to 0.88), 0.80 (0.73 to 0.88) and 0.84 (0.71 to 1.00) for incident CVD, CHD and stroke, respectively. Compared with participants with 13.2 ≤ PDW ≤ 18.1 %, the adjusted HRs (95% CIs) of those with PDW < 13.2 % were 0.80 (0.73 to 0.87) and 0.78 (0.70 to 0.86) for incident CVD and CHD, respectively. In conclusion, lower levels of PLT and MPV were significantly related to lower risk of stroke, while lower levels of MPV and PDW were significantly related to lower risks of CVD and CHD.
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