Related Experiment Video
Updated: Feb 2, 2026

A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction
Published on: July 18, 2025
Medium and long-term outcomes of gastroschisis
Janne Suominen1, Risto Rintala1
1Department of Paediatric Surgery, Children's Hospital, University of Helsinki, P.O. Box 281, Helsinki FIN-00029 HUS, Finland.
Insights
Improved gastroschisis survival necessitates better long-term care. Beyond gastrointestinal issues, patients face neurodevelopmental, cognitive, behavioral, and auditory challenges, requiring multidisciplinary follow-up.
Area of Science:
- Pediatric Surgery
- Developmental Pediatrics
- Neonatology
Background:
- Gastroschisis survival rates have significantly improved.
- Longitudinal follow-up strategies are now essential.
- Gastrointestinal morbidity is common, but other sequelae are increasingly recognized.
Purpose of the Study:
- To highlight the need for comprehensive, multidisciplinary follow-up for gastroschisis patients.
- To outline the key elements of effective long-term care strategies.
- To address the expanding spectrum of gastroschisis-related morbidities.
Main Methods:
- Review of current literature on gastroschisis outcomes.
- Analysis of long-term sequelae beyond gastrointestinal issues.
- Synthesis of recommendations for multidisciplinary care models.
Main Results:
- Gastroschisis patients experience significant gastrointestinal morbidity.
- Neurodevelopmental, cognitive, behavioral, and auditory issues are prevalent.
- Associated anomalies and complex abdominal wall defects exacerbate outcomes.
Conclusions:
- Multidisciplinary follow-up is crucial for optimizing long-term outcomes in gastroschisis survivors.
- Care must address both gastrointestinal and non-gastrointestinal sequelae.
- Standardized follow-up protocols are needed to manage complex patient needs.
Abstract:
As survival of gastroschisis patients has improved significantly, it has become apparent that longitudinal follow up strategies need to be developed. Problems concerning patients with gastroschisis are usually associated with gastrointestinal morbidity, but there is mounting evidence that also neurodevelopmental, cognitive, behavioral and late-onset auditory sequelae exist. The presence of associated anomalies, as well as complex features (bowel atresia, necrosis, volvulus, perforation) increase morbidity and impact long-term outcomes. Multidisciplinary follow-up is required, and the key elements of such follow-up are presented here.
Related Concept Videos
Predicting Reaction Outcomes
Outcomes of Glycolysis
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
Long-term Depression
Long-term Depression
Calcium Ion Concentration Mechanism
If over...
Guidelines for Writing Outcome
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
Regional Terms
Primarily, the human body has two major regions, the axial and appendicular regions. The axial region comprises regions from the head to the abdomen and makes up the central body axis. In contrast,...

