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Dulaglutide-induced cerebral venous thrombosis in a patient with type 2 diabetes mellitus

Rajesh Rajput1, Vaibhav Pathak1, Pawan Kumar Yadav1,2

  • 1Department of Endocrinology and Medicine Unit V, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.

BMJ Case Reports
|November 11, 2018
PubMed

Insights

Patients with diabetes on dulaglutide experienced cerebral venous thrombosis. This event was linked to severe dehydration from drug-induced nausea and vomiting, not diabetes itself.

Area of Science:

  • Neurology
  • Endocrinology
  • Pharmacology

Background:

  • Diabetes mellitus increases atherothrombotic event risk.
  • Cerebral venous thrombosis (CVT) requires thorough investigation beyond underlying conditions.

Observation:

  • A patient with diabetes presented with headache and blurred vision.
  • The patient was receiving subcutaneous dulaglutide and experiencing nausea and vomiting.
  • Brain imaging showed right transverse sinus thrombosis and acute infarct.

Findings:

  • Extensive investigations ruled out common causes of cerebral venous thrombosis.
  • The CVT was ultimately attributed to severe dehydration secondary to dulaglutide-induced nausea and vomiting.

Implications:

  • Highlights potential adverse effects of GLP-1 receptor agonists like dulaglutide.
  • Emphasizes the need to consider drug side effects in unexplained thrombotic events.
  • Suggests vigilant monitoring for dehydration in patients on dulaglutide therapy.

Keywords:
diabetesstroke

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