Related Experiment Video

Updated: Feb 2, 2026

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
07:04

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Published on: May 2, 2025

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PD-Loma: a cancer entity with a shared sensitivity to the PD-1/PD-L1 pathway blockade

Laure Hirsch1, Laurence Zitvogel2, Alexander Eggermont3

  • 1Département d'Innovation Thérapeutique et d'Essais Précoces, Gustave Roussy, Université Paris-Saclay, Villejuif, F-94805, France.

British Journal of Cancer
|November 11, 2018
PubMed

Insights

Over 30 cancer types respond to anti-programmed death (ligand) 1 therapies, marking a significant advance in oncology. This broad efficacy is shaping future combination immunotherapy research strategies.

Area of Science:

  • Oncology
  • Immunotherapy
  • Cancer Research

Background:

  • Over 30 distinct cancer histotypes demonstrate sensitivity to anti-programmed death-1 (PD-1) and anti-programmed death-ligand 1 (PD-L1) therapies.
  • This represents an unprecedented breadth of monotherapy activity for a drug class in oncology.

Discussion:

  • The identification of these sensitive cancers, termed 'PD-Lomas', is a pivotal development.
  • This broad-spectrum efficacy highlights the potential of targeting the PD-1/PD-L1 pathway across diverse malignancies.

Key Insights:

  • Monotherapy with anti-PD-(L)1 agents shows efficacy in over 30 cancer histotypes.
  • This wide applicability establishes a new paradigm in cancer treatment.

Outlook:

  • 'PD-Lomas' are now central to designing next-generation combination immunotherapy clinical trials.
  • Future research will likely focus on optimizing combination strategies to further enhance patient outcomes.

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